Method of providing frozen composition and device therefor

1 . A spraying system to spray a composition and a coolant to a skin, the spraying system comprising:

a composition storage configured to store the composition;

a coolant storage spaced apart from the composition storage and configured to store the coolant at a first temperature;

a nozzle configured to continuously spray the coolant toward a target area of the skin via a discharge port thereof such that the continuously sprayed coolant forms a coolant stream having a second temperature;

a valve configured to transport the coolant from the coolant storage to the nozzle;

a composition guide structure configured to guide the composition from the composition storage into the coolant stream such that the composition meets and moves within the coolant stream at a region outside the nozzle,

the composition guide structure comprising a body, an input end and an output end disposed on opposing sides of the body, wherein the body, the input end, and the output end are integrally formed as a single guide structure defining the composition guide structure, the body being disposed offset from a central axis of the nozzle,

the input end configured as an inlet for introducing the composition from the composition storage into the composition guide structure,

the body configured to guide the composition from the input end to the output end within the composition guide structure,

the output end configured as an outlet for discharging the composition into the coolant stream, and

the output end being positioned outside the nozzle and adjacent to the discharge port of the nozzle such that the composition discharged from the output end meets the coolant stream at the region outside the nozzle, the composition having a third temperature after being discharged from the output end and before being mixed with the coolant stream, the third temperature being higher than the second temperature;

an actuator operatively coupled with the composition storage and the composition guide structure, the actuator configured to pressurize the composition in the composition storage so that the composition is released from the composition storage, introduced into the input end of the composition guide structure, flows along the body of the composition guide structure, and is discharged from the output end of the composition guide structure into the coolant stream outside the nozzle;

a temperature regulator configured to regulate a temperature of the coolant by heating the coolant before the coolant is transported into the nozzle and before the coolant stream meets the composition such that the temperature of the coolant at the temperature regulator increases from the first temperature to a fourth temperature higher than the first temperature; and

a controller configured to:

control the temperature regulator to maintain the temperature of the target area at a target temperature sufficient to:

cause at least part of the composition to convert into a plurality of frozen composition particles by mixing the coolant stream having the second temperature with the composition having the third temperature while moving in the coolant stream at the region outside the nozzle, at least some of the plurality of frozen composition particles having a size sufficient to collide with and penetrate into the target area of the skin, and

prevent formation of an ice layer on the target area of the skin that would at least partially block penetration of the plurality of frozen composition particles,

wherein the temperature regulator is configured to heat the coolant before the coolant reaches the nozzle to maintain the target temperature at or above 0 degrees Celsius or 3 degrees Celsius, so as to increase the temperature of the coolant stream and reduce a number of the plurality of frozen composition particles at the region outside the nozzle, while ensuring both particle penetration and prevention of ice layer formation, as compared to a condition in which the coolant is not heated before reaching the nozzle, such that an amount of the composition penetrating into the target area of the skin is increased due to prevention of formation of the ice layer.

2 . The spraying system of claim 1 , wherein the controller is configured to:

control the temperature regulator to regulate the temperature of the coolant enabling the coolant to cause at least 2%, at least 5% or at least 17% of the at least part of the composition being converted into the plurality of frozen composition particles within a predetermined observation region, and

wherein each of the plurality of frozen composition particles is not in a gaseous state.

3 . The spraying system of claim 2 , wherein the predetermined observation region is configured at a predetermined distance from the target area.

4 . The spraying system of claim 1 , wherein the temperature of the coolant stream is configured to be regulated to be insufficient to form the ice layer due to a temperature of the target area which is higher than the temperature of the coolant stream while the temperature of the coolant stream still causes the at least some of the composition to be converted into the plurality of frozen composition particles.

5 . The spraying system of claim 1 , further comprising:

a distance maintaining part configured to maintain a distance between the nozzle and the target area.

6 . The spraying system of claim 1 , wherein the output end of the composition guide structure is spaced apart from the discharge port of the nozzle by a first distance in a direction parallel to a central axis of the nozzle and by a second distance in a direction orthogonal to the central axis of the nozzle.

7 . The spraying system of claim 1 , wherein the composition guide structure comprises a composition guide plate.

8 . The spraying system of claim 1 , wherein the controller is further configured to control the temperature regulator to regulate the temperature of the target area to cause a freeze ratio of the composition to be in a range of 2% and 74% and prevent ice layer formation on the target area of the skin by maintaining the target temperature at or above 0 degrees Celsius or 3 degrees Celsius.

9 . A method of penetrating a composition into a skin of a subject using a spraying system, the method comprising:

providing the spraying system, wherein the spraying system comprises a composition storage configured to store the composition, a composition guide structure, an actuator, a nozzle, a valve, a temperature regulator, a coolant storage configured to store a coolant at a first temperature, a coolant storage connector coupled to the coolant storage and a spraying hole through which a coolant stream sprayed from the nozzle is sprayed together with the composition, the coolant stream having a second temperature,

the composition guide structure configured to guide the composition from the composition storage into the coolant stream such that the composition meets and moves within the coolant stream at a region outside the nozzle,

the composition guide structure comprising a body, an input end and an output end disposed on opposing sides of the body, wherein the body, the input end, and the output end are integrally formed as a single guide structure defining the composition guide structure, the body being disposed offset from a central axis of the nozzle,

the composition having a third temperature after being discharged from the output end and before being mixed with the coolant stream, the third temperature being higher than the second temperature,

the actuator operatively coupled with the composition storage and the composition guide structure, the actuator configured to pressurize the composition in the composition storage so that the composition is released from the composition storage, introduced into the input end of the composition guide structure, flows along the body of the composition guide structure, and is discharged from the output end of the composition guide structure into the coolant stream outside the nozzle;

positioning the spraying hole of the spraying system to face a target area which is a part of the skin; and

operating the spraying system to:

regulate a temperature of the coolant, being transported into the nozzle, by heating the coolant before the coolant meeting the composition, such that the temperature of the coolant at the temperature regulator increases from the first temperature to a fourth temperature higher than the first temperature, to maintain the temperature of the target area at a target temperature to:

cause at least part of the composition to convert into a plurality of frozen composition particles by mixing the coolant stream having the second temperature with the composition having the third temperature while moving in the coolant stream at the region outside the nozzle, at least some of the plurality of frozen composition particles having a size sufficient to collide with and penetrate into the target area of the skin, and

prevent formation of an ice layer on the target area of the skin that would at least partially block penetration of the plurality of frozen composition particles; and

spray the coolant stream to meet the composition at the region outside the nozzle and to be delivered toward the target region together with the composition,

wherein the temperature regulator is configured to heat the coolant before the coolant reaches the nozzle to maintain the target temperature at or above 0 degrees Celsius or 3 degrees Celsius, so as to increase the temperature of the coolant stream and reduce a number of the plurality of frozen composition particles at the region outside the nozzle, while ensuring both particle penetration and prevention of ice layer formation, as compared to a condition in which the coolant is not heated before reaching the nozzle, such that an amount of the composition penetrating into the target area of the skin is increased due to prevention of formation of the ice layer.

10 . The method of claim 9 , wherein operating the spraying system comprises:

operating the spraying system to regulate the coolant passing through the temperature regulator such that the coolant to be sprayed from the nozzle causes at least 2%, at least 5% or at least 17% of the composition mixed with the coolant stream converted into the plurality of frozen composition particles within a predetermined observation region, and

wherein each of the plurality of frozen composition particles is not in a gaseous state.

11 . The method of claim 10 , wherein the predetermined observation region is configured at a predetermined distance from the target area.

12 . The method of claim 9 , wherein the temperature of the coolant stream to be sprayed from the nozzle is regulated to be insufficient to form the ice layer due to a temperature of the target area which is higher than the temperature of the sprayed coolant while the temperature of the coolant stream still causes the at least part of the composition to be converted into the plurality of frozen composition particles.

13 . The method of claim 9 , wherein the spraying system further comprises a distance maintain part, and

wherein positioning the spraying hole of the spraying system comprises:

positioning the spraying hole of the spraying system at a distance between the spraying hole and the target area to be maintained by the distance maintain part.