Systems, devices, methods, and computer-readable media for analysis of bodily fluids and methods for its use in clinical decision-making
Systems, devices, methods, and computer-readable media may use broad-range spectrophotometric analysis and/or other sensors to generate data from bodily fluids accessed via a fluid drain. These data may be utilized to analyze therapeutic efficacy, to enable early detection of complications, and to guide the clinical management of patients being treated with a fluid drain. Advantageously, these systems, devices, methods, and computer-readable media enable clinical patient care decisions to be performed in a manner that is data-driven or quantitative in nature as opposed to qualitative—e.g., via well-defined, algorithmic-based processes and/or reliable methods. As a result, these systems, devices, methods, and computer-readable media enable improved clinical outcomes, more efficiently optimized medical care, and cost savings.
1 . A fluid diagnostic device, comprising:
a spectrophotometry sensor operable to generate output information as a function of one or more wavelengths of reference light that is emitted by one or more signal emitting portions of the spectrophotometry sensor and that passes through fluid within a length of tubing;
a tubing holder that is configured to secure the length of tubing in a fixed position and orientation relative to the spectrophotometry sensor, wherein the tubular conduit holder includes a first tubular conduit constraining body and a second tubular conduit constraining body, wherein the tubular conduit constraining bodies jointly define a tubular conduit receiving space and wherein at least one of the tubular conduit constraining bodies is movable relative to the other for enabling at a width of the tubular conduit receiving space to be adjustable for accommodating tubular conduits having different outside dimension;
a functionality control module operable to determine a responsive action as a function of at least a portion of the output information, wherein determination of the responsive action is initiated in response to at least a portion of the output information indicating an unacceptable deviation of a current condition of the fluid from a baseline condition of the fluid and wherein the current and baseline conditions of the fluid relate to presence of a biomarker within the fluid;
a strain gauge attached to an exterior surface of the length of tubing, wherein the fluid-carrying portion of the tubular conduit coupler is a length of resilient tubing, wherein the tubular conduit is resilient tubing having known material and physical specifications and wherein the functionality control module computes strain as a function of strain gauge output and the known material and physical specifications;
a tubular conduit coupler that comprises the length of tubing, wherein the tubular conduit coupler is connectable to a fluid conduit of a fluid drain;
a fluid flow shutoff for selectively inhibiting flow of the fluid through the length of tubing; and
at least one sensor operable for determining a parameter that arises from the fluid being static within the length of tubing;
wherein at least one of the spectrophotometry sensor and the functionality control module is operable to correlate the at least one wavelength of the light to the parameter characterizing the presence of the biomarker within the fluid.
2 . The fluid diagnostic device of claim 1 wherein the functionality control module being operable to determine the responsive action includes the functionality control module being operable to determine at least one of the biomarker not being detectable within the fluid and an amount of the biomarker being below a prescribed threshold.
3 . The fluid diagnostic device of claim 1 wherein:
at least one of the spectrophotometry sensor and the functionality control module is operable to detect the biomarker within the fluid; and
the functionality control module is coupled to the spectrophotometry sensor for enabling an output signal including information generated by the spectrophotometry sensor to be transmitted therefrom for reception by the functionality control module.
4 . The fluid diagnostic device of claim 3 wherein the functionality control module being operable to determine the responsive action includes the functionality control module being operable to determine at least one of the biomarker not being detectable within the fluid and an amount of the biomarker being below a prescribed threshold.
5 . The fluid diagnostic device of claim 1 wherein at least one of the spectrophotometry sensor and the functionality control module is operable to detect the biomarker within the fluid.
6 . The fluid diagnostic device of claim 5 wherein the functionality control module being operable to determine the responsive action includes the functionality control module being operable to determine at least one of the biomarker not being detectable within the fluid and an amount of the biomarker being below a prescribed threshold.
7 . The fluid diagnostic device of claim 1 wherein the functionality control module is coupled to the spectrophotometry sensor for enabling an output signal including information generated by the spectrophotometry sensor to be transmitted therefrom for reception by the functionality control module.
8 . The fluid diagnostic device of claim 7 wherein the functionality control module being operable to determine the responsive action includes the functionality control module being operable to determine at least one of the biomarker not being detectable within the fluid and an amount of the biomarker being below a prescribed threshold.
9 . The fluid diagnostic device of claim 1 wherein the functionality control module is operable to correlate the at least one wavelength of the light to the parameter characterizing the presence of the biomarker within the fluid.
10 . The fluid diagnostic device of claim 9 wherein the functionality control module being operable to determine the responsive action includes the functionality control module being operable to determine at least one of the biomarker not being detectable within the fluid and an amount of the biomarker being below a prescribed threshold.
11 . The fluid diagnostic device of claim 1 wherein the spectrophotometry sensor is operable to detect the biomarker within the fluid.
12 . The fluid diagnostic device of claim 11 wherein the functionality control module being operable to determine the responsive action includes the functionality control module being operable to determine at least one of the biomarker not being detectable within the fluid and an amount of the biomarker being below a prescribed threshold.
13 . The fluid diagnostic device of claim 12 wherein the functionality control module being operable to determine the responsive action includes the functionality control module being operable to determine at least one of the biomarker not being detectable within the fluid and an amount of the biomarker being below a prescribed threshold.
14 . The fluid diagnostic device of claim 12 wherein the functionality control module is operable to correlate the at least one wavelength of the light to the parameter characterizing the presence of the biomarker within the fluid.
15 . The fluid diagnostic device of claim 14 wherein the functionality control module being operable to determine the responsive action includes the functionality control module being operable to determine at least one of the biomarker not being detectable within the fluid and an amount of the biomarker being below a prescribed threshold.