4-Methoxy-2-phenethyl isoindoline-1-one derivative and composition for treating neurological diseases, comprising same
The present invention relates to: a novel 4-methoxy-2-phenethyl isoindolin-1-one derivative compound having the ability to promote the increase of nerve growth factor, the ability to promote the growth of nerve cells, and antineuritic activity; and a composition for preventing, improving and treating neurological diseases, comprising the same.
1 . A compound represented by Formula 9 below or a pharmaceutically acceptable salt thereof:
in the formula,
R 1 is hydrogen, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, hydroxyalkyl, alkoxyalkyl, or —N(Ra)(Rb);
R 2 , R 3 , R 4 , Ra and Rb are each independently hydrogen or alkyl; and
X is a single bond or a double bond.
2 . The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein
R 1 is hydrogen, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, hydroxyalkyl, alkoxyalkyl, or —N(Ra)(Rb);
Ra and Rb are each independently hydrogen or alkyl;
R 2 and R 4 are hydrogen;
R 3 is alkyl; and
X is a single bond or a double bond.
3 . The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein
R 1 is C 1 -C 6 alkyl, hydroxy, C 1 -C 6 hydroxyalkyl, or —N(Ra)(Rb);
Ra and Rb are each independently C 1 -C 6 alkyl;
R 2 and R 4 are hydrogen;
R 3 is C 1 -C 6 alkyl; and
X is a single bond or a double bond.
4 . A compound selected from the group consisting of compounds of the following formulas or a pharmaceutically acceptable salt thereof:
5 . A pharmaceutical composition for preventing or treating neurological diseases, comprising the compound represented by Formula 9 or the pharmaceutically acceptable salt thereof according to claim 1 .
6 . A food composition for preventing or improving neurological diseases, comprising the compound represented by Formula 9 or the pharmaceutically acceptable salt thereof according to claim 1 .
7 . A feed composition for preventing or improving neurological diseases, comprising the compound represented by Formula 9 or the pharmaceutically acceptable salt thereof according to claim 1 .
8 . A method for preventing or treating neurological diseases, the method comprising administering the compound represented by Formula 9 or the pharmaceutically acceptable salt thereof according to claim 1 to a subject in need thereof.
9 . A method for preventing or treating neurological diseases, the method comprising administering the compound or the pharmaceutically acceptable salt thereof according to claim 4 to a subject in need thereof.