IP Library › Granted Patent US 12703698
Granted Patent B2
US 12703698 · App. 18/017,759 · Granted Aug 11, 2026

Inhibitors of interleukin-1 receptor-associated kinases 1 and 4

Inventors: Michael Becker (Rochester, NY); Rakesh Singh (Rochester, NY); Richard Moore (Rochester, NY); Laura Calvi (Rochester, NY)
Assignee: The University of Rochester
C07D417/02A61K45/06A61P35/00
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Quick Facts
Patent No.
US 12703698
App. No.
18/017,759
Granted
Aug 11, 2026
Kind
B2
Abstract

The present disclosure provides compounds that are inhibitors of interleukin-1 receptor-associated kinases 1 and 4 (IRAK1 and IRAK4) and their use in the treatment of medical disorders such as autoimmune disorders, cancer, and pain disorders.

Claims (4)

1 . A compound selected from:

or a pharmaceutically acceptable salt thereof.

2 . A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

3 . A method for ameliorating pancreatic cancer, leukemia, and myeloma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.