IP Library › Granted Patent US 12703700
Granted Patent B2
US 12703700 · App. 19/271,553 · Granted Aug 11, 2026

GLP-1R agonist and therapeutic method thereof

Inventors: Bin Liang (Hong Kong, CN); Jinzi Jason Wu (Hong Kong, CN); Bailing Yang (Hong Kong, CN)
Assignee: ASCLETIS PHARMA (CHINA) CO., LIMITED
C07D471/04A61K31/437C07D519/00
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Quick Facts
Patent No.
US 12703700
App. No.
19/271,553
Granted
Aug 11, 2026
Kind
B2
Abstract

The present disclosure describes GLP-1R modulating compounds that are useful for treating GLP-1R-mediated diseases or conditions,

Claims (4)

1 . A process for preparing compound 1, comprising reacting compound A and compound O-6 or salts thereof to give the compound 1,

2 . The process of claim 1 , wherein a condensation reaction is carried out in the presence of a condensing agent and a base.

3 . The process of claim 2 , wherein the condensing agent is selected from the group consisting of EDC, EDCI, DIC, DCC, TBTU, HATU, HBTU, HCTU, DEPBT, PyBOP, T3P, T4P, and PyAOP.

4 . The process of claim 2 , wherein the base is selected from the group consisting of DIPEA, DIEA, Et3N, NMP, DBU, Pyridine, K 2 CO 3 , Na 2 CO 3 , NaHCO 3 , and DABCO.