Compositions and compounds for co-delivery of uridine and ketoleucine
Compounds and compositions that deliver both uridine and ketoleucine are useful in treating disorders characterized by diminished muscle strength or diminished muscle lean mass. One such a compound is 5′-O-ketoleucyl-2′,3′-di-O-acetyluridine.
1 . A compound, 5′-O-ketoleucyl-2′,3′-di-O-acetyluridine.
2 . A method of treating a disorder characterized by diminished muscle strength or diminished muscle lean mass in a mammalian subject, comprising administering to the mammalian subject an amount of the compound of claim 1 effective to treat the disorder.
3 . The method of claim 2 , wherein the disorder is selected from the group consisting of muscle-wasting conditions; dynapenia; muscle disuse atrophy; and the muscle wasting and exercise tolerance associated with chronic kidney disease, chronic obstructive pulmonary disease, and chronic heart failure.
4 . The method of claim 3 wherein the muscle-wasting condition is selected from the group consisting of sarcopenia and cachexia.
5 . The method of claim 2 , wherein the mammalian subject is a human subject.
6 . The method of claim 3 , wherein the mammalian subject is a human subject.
7 . The method of claim 4 , wherein the mammalian subject is a human subject.