IP Library Granted Patent US 12703768
Granted Patent B2
US 12703768 · App. 17/921,588 · Granted Aug 11, 2026

Degradable bio-based polymers

Inventors: Stephen Mayfield (La Jolla, CA); Robert Pomeroy (La Jolla, CA); Michael Burkart (La Jolla, CA); Natasha Gunawan (La Jolla, CA); Ariel Schreiman (La Jolla, CA); Marissa Tessman (Cardiff, CA); Nitin Neelakantan (Cardiff, CA); Ryan Simkovsky (La Jolla, CA)
Assignees: The Regents of the University of California; Algenesis Corporation
C08G18/4238C08J11/10C08J11/105C08G2101/00C08G2230/00C08J2375/06
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Quick Facts
Patent No.
US 12703768
App. No.
17/921,588
Granted
Aug 11, 2026
Kind
B2
Abstract

Disclosed herein are bio-based polymers, methods to prepare the same, bio-based polymer products, methods to degrade the same, and methods to recycle the same.

Claims (41)

1 . A method to biodegrade a bio-based polymer product, the method comprising incubating the bio-based polymer product with a first microorganism, wherein:

the bio-based polymer product comprises a bio-based polymer;

the bio-based polymer is a polyurethane; and

incubation of the bio-based polymer product with the first microorganism degrades the bio-based polymer to subunits comprising a di-carboxylic acid, a diol, or a combination thereof; wherein the diol is selected from ethylene glycol; 1,2 propanediol; 1,3-propanediol; glycerol; 1,3-butanediol; 1,4-butanediol; 2-methyl-1,3-propanediol; 2,3-butanediol; trimethylolpropane; 1,5-pentanediol; 1,6-hexanediol; 3-methyl-1,5-pentanediol; 1,7-heptanediol; 1,8-octanediol; 1,9-nonanediol; 1,10-decanediol; or a combination of two or more thereof; and wherein the bio-based polymer product further comprises a rate-regulating compound, and the rate-regulating compound comprises a salt selected from CaCl 2 , Na 2 HPO 4 , KH 2 PO 4 , NaCl, NH 4 Cl, MgSO 4 , NaNO 3 , NaH 2 PO 4 , FeCl 3 , or a combination of two or more thereof.

2 . The method of claim 1 , wherein the polyurethane is a polymerization product of one or more linear aliphatic polyester polyols, and a diisocyanate.

3 . The method of claim 2 , wherein the one or more linear aliphatic polyester polyols are produced from one or more biologically sourced diols and one or more biologically sourced di-carboxylic acids.

4 . The method of claim 3 , wherein the one or more biologically sourced diols, the one or more biologically sourced di-carboxylic acids, or a combination thereof are derived from algae.

5 . The method of claim 3 , wherein the one or more biologically sourced diols or the one or more biologically sourced di-carboxylic acids are non-branched, or the one or more biologically sourced diols and the one or more biologically sourced di-carboxylic acids are non-branched.

6 . The method of claim 3 , wherein the one or more biologically sourced diols and the one or more biologically sourced di-carboxylic acids are branched.

7 . The method of claim 3 , wherein the one or more biologically sourced diols or the one or more biologically sourced di-carboxylic acids have a carbon chain length of 2-4 carbons, or the one or more biologically sourced diols and the one or more biologically sourced di-carboxylic acids have a carbon chain length of 2-4 carbons.

8 . The method of claim 3 , wherein the one or more biologically sourced di-carboxylic acids have a carbon chain length of 5-20 carbons.

9 . The method of claim 1 , wherein the bio-based polymer product comprises a foam.

10 . The method of claim 1 , wherein the bio-based polymer product comprises a thermal plastic polyurethane (TPU).

11 . The method of claim 1 , wherein the first microorganism is selected from the group consisting of Paenarthrobacter nicotinovorans, Pseudomonas oceani, Pseudomonas aeruginosa, Alteromonas marina, Bacillus subtilis, Brucella melitensis , and Aspergillus fumigatus.

12 . The method of claim 1 , wherein the subunits comprise a di-carboxylic acid, a diol, or a combination of two or more thereof, wherein the di-carboxylic acid is independently selected from the group consisting of oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, and sebacic acid.

13 . A method to degrade a bio-based polymer product, the method comprising incubating the bio-based polymer product with an acid or a base, wherein:

the bio-based polymer product comprises a bio-based polymer;

the bio-based polymer is a polyurethane;

the acid is selected from hydrochloric acid, nitric acid, sulfuric acid, hydrobromic acid, hydroiodic acid, or perchloric acid, or a combination of two or more thereof,

the base is selected from lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, strontium hydroxide, or barium hydroxide, or a combination of two or more thereof, and

incubation of the bio-based polymer product with the acid or the base degrades the bio-based polymer to subunits comprising a di-carboxylic acid, a diol, or a combination thereof; wherein the diol is selected from ethylene glycol; 1,2 propanediol; 1,3-propanediol; glycerol; 1,3-butanediol; 1,4-butanediol; 2-methyl-1,3-propanediol; 2,3-butanediol; trimethylolpropane; 1,5-pentanediol; 1,6-hexanediol; 3-methyl-1,5-pentanediol; 1,7-heptanediol; 1,8-octanediol; 1,9-nonanediol; 1,10-decanediol; or a combination of two or more thereof.

14 . A method of recycling a bio-based polymer product, the method comprising:

incubating a bio-based polymer product under a condition to generate a mixture of subunits from depolymerization of the bio-based polymer;

purifying the mixture to obtain one or more isolated subunits; and

synthesizing a pre-polymer comprising at least one of the one or more isolated subunits;

wherein

the bio-based polymer product comprises a bio-based polymer;

the bio-based polymer is a polyurethane; and

the subunits comprise a di-carboxylic acid, a diol, or a combination thereof; wherein the diol is selected from ethylene glycol; 1,2 propanediol; 1,3-propanediol; glycerol; 1,3-butanediol; 1,4-butanediol; 2-methyl-1,3-propanediol; 2,3-butanediol; trimethylolpropane; 1,5-pentanediol; 1,6-hexanediol; 3-methyl-1,5-pentanediol; 1,7-heptanediol; 1,8-octanediol; 1,9-nonanediol; 1,10-decanediol; or a combination of two or more thereof.

15 . The method of claim 1 , further comprising isolating the subunits.

16 . The method of claim 13 , further comprising isolating the subunits.

17 . The method of claim 13 , wherein the bio-based polymer product further comprises a rate-regulating compound, wherein the rate-regulating compound comprises a mineral, a salt, a vitamin, or a combination of two or more thereof;

wherein the mineral is selected from the group consisting of nitrogen, potassium, phosphate, iron, calcium, sulfur, magnesium, cobalt, zinc, and a combination of two or more thereof;

wherein the salt is selected from CaCl 2 , Na 2 HPO 4 , KH 2 PO 4 , NaCl, NH 4 Cl, MgSO 4 , NaNO 3 , NaH 2 PO 4 , FeCl 3 , or a combination of two or more thereof, and

wherein the vitamin is selected from p-aminobenzoic acid (PABA), folic acid, biotin, lipoic acid, mercaptoethane-sulfonic acid, nicotinic acid, pantothenic acid, pyridoxine (B6), riboflavin (B2), thiamine (B1), vitamin B12, or vitamin K, or a combination of two or more thereof.

18 . The method of claim 13 , wherein the polyurethane is in the form of a foam, a thermal plastic polyurethane (TPU), or an adhesive.

19 . The method of claim 14 , wherein the bio-based polymer product further comprises a rate-regulating compound, wherein the rate-regulating compound comprises a mineral, a salt, a vitamin, or a combination of two or more thereof;

wherein the mineral is selected from the group consisting of nitrogen, potassium, phosphate, iron, calcium, sulfur, magnesium, cobalt, zinc, and a combination of two or more thereof;

wherein the salt is selected from CaCl 2 , Na 2 HPO 4 , KH 2 PO 4 , NaCl, NH 4 Cl, MgSO 4 , NaNO 3 , NaH 2 PO 4 , FeCl 3 , or a combination of two or more thereof; and

wherein the vitamin is selected from p-aminobenzoic acid (PABA), folic acid, biotin, lipoic acid, mercaptoethane-sulfonic acid, nicotinic acid, pantothenic acid, pyridoxine (B6), riboflavin (B2), thiamine (B1), vitamin B12, or vitamin K, or a combination of two or more thereof.

20 . The method of claim 14 , wherein the polyurethane is in the form of a foam, a thermal plastic polyurethane (TPU), or an adhesive.