Antimicrobial coating compositions and residual antimicrobial coatings resulting therefrom
Aqueous coating compositions are disclosed that are capable of forming residual antimicrobial coatings having improved performance related to residual efficacy and duration. In various embodiments, an antimicrobial coating composition comprises at least one antimicrobial compound, at least one durable matrix forming compound, and optionally, at least one performance-enhancing additive. The antimicrobial compound is selected from non-silane quaternary compounds and quaternary silanes. The durable matrix forming compound is selected from polymers, non-polymeric organic compounds, inorganic substances, additional antimicrobial substances, reactive silanes, and non-reactive silanes. The performance-enhancing additive is selected from a polymer, a solvent, an inorganic substance, a surfactant, a crosslinker, a surface modifier, and chemical species capable of forming a sol-gel.
1 . An antimicrobial coating composition comprising:
at least one antimicrobial compound;
at least one durable matrix forming compound selected from at least one organosilane;
optionally, at least one performance-enhancing additive which is a cross-linker; and,
water.
2 . The antimicrobial coating composition of claim 1 , wherein the at least one antimicrobial compound is selected from the group consisting of non-silane cationic quaternary compounds, Chlorhexidine digluconate, Chlorhexidine diacetate, cationic peptidopolysaccharides, ionenes, polyhexamethylene biguanide (PHMB) polyethylenimines (PEIs), ionic poly [2-(tert-butylaminoethyl) methacrylate] (PTBAM), and mixtures thereof.
3 . The antimicrobial coating composition of claim 1 , wherein the at least one durable matrix forming compound comprises a mixture of hydrophobic and hydrophilic organosilanes.
4 . The antimicrobial coating composition of claim 1 , wherein the water is replaced with at from about 0.0 wt. % to about 60 wt. % of a water-miscible solvent based on the total weight of the antimicrobial coating composition.
5 . The antimicrobial coating composition of claim 1 , wherein the antimicrobial compound is present at from about 0.01 wt. % to about 4 wt. %, based on the total weight of the antimicrobial coating composition.
6 . The antimicrobial coating composition of claim 1 , wherein the durable matrix forming compound is present at from about 0.01 wt. % to about 15 wt. %, based on the total weight of the antimicrobial coating composition.
7 . The antimicrobial coating composition of claim 1 , wherein the performance-enhancing additive is present at from about 0.0 wt. % to about 8 wt. %, based on the total weight of the antimicrobial coating composition.
8 . The antimicrobial coating composition of claim 1 , wherein the antimicrobial coating is substantially haze-free.
9 . The antimicrobial coating composition of claim 1 , wherein the antimicrobial coating exhibits substantially no oil residue.
10 . The antimicrobial coating composition of claim 1 , wherein the antimicrobial coating is substantially tack-free.
11 . The antimicrobial coating composition of claim 3 , wherein
the hydrophilic silane is selected from aminopropyltriethoxysilane, 3-aminopropyl(diethoxy)methylsilane, trimethoxy[3-(methylamino)propyl]silane, N-[3-(trimethoxysilyl)propyl]ethylenediamine, 3-(2-aminoethylamino)propyldimethoxymethylsilane, N1-(3-trimethoxysilylpropyl)diethylenetriamine and N-[3-(trimethoxysilyl)propyl]butan-1-amine;
the hydrophobic silane is selected from methyltriethoxysilane, ethyltriethoxysilane, propyltriethoxysilane, dimethyldimethoxysilane, bis(triethoxysilyl) methane and bis(triethoxysilyl) ethane; and
the cross-linker is selected from AlCl 3 , B(OH) 3 , TiCl 4 , Ti(OiPr) 4 , SiCl 4 , Si(OMe) 4 , Si(OEt) 4 , pentaerythritol and neopentylglycol.