IP Library › Granted Patent US 12708639
Granted Patent B2
US 12708639 · App. 17/595,166 · Granted Aug 18, 2026

Compositions and methods to treat or prevent metabolic fatigue using the compound oleuropein or a metabolite thereof

Inventors: Umberto De Marchi (Corminboeuf, CH); Marie Noelle Horcajada (Echenevex, FR); Jerome Feige (Crissier, CH); Cristina Mammucari (Padua, IT); Bert Blaauw (Padua, IT)
Assignee: Societe des Produits Nestle S.A.
A61K31/7048A23L33/125A61P43/00
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Quick Facts
Patent No.
US 12708639
App. No.
17/595,166
Granted
Aug 18, 2026
Kind
B2
Abstract

At least one of oleuropein or metabolite thereof can be orally administered to an individual in an amount effective to achieve at least one result that is one or more of (i) improvement in a physiological state linked to metabolic fatigue in one or more cells, (ii) increased mitochondrial energy and mitochondrial calcium uptake in one or more cells, and/or (iii) treatment or prevention of a calcium deficiency/depletion disorder. Additionally or alternatively, the method can treat or prevent a mitochondria-related disease or a condition associated with altered mitochondrial function in an individual in need thereof or at risk thereof.

Claims (10)

1 . A method of treatment or prevention of a calcium deficiency/depletion disorder in an individual in need thereof, the method comprising orally administering to the individual a composition comprising an effective amount of a compound selected from the group consisting of oleuropein aglycone, homovanillyl alcohol, isohomovanillyl alcohol, and combinations thereof.

2 . The method of claim 1 , wherein the composition is orally administered daily for at least one week.

3 . The method of claim 1 , wherein the composition is selected from the group consisting of food compositions, dietary supplements, nutritional compositions, nutraceuticals, beverages, powdered nutritional products to be reconstituted in water or milk before consumption, food additives, medicaments, drinks, petfood, and combinations thereof.

4 . The method of claim 1 , wherein the composition further comprises calcium.

5 . The method of claim 1 , wherein the composition is a food product further comprising a component selected from the group consisting of protein, carbohydrate, fat, and combinations thereof.

6 . The method of claim 4 , wherein the composition comprises the calcium in an amount from about 200 mg to about 800 mg.

7 . The method of claim 1 , wherein the composition is administered for a time period of at least two days per week for at least two months.

8 . The method of claim 1 , wherein at least a portion of the effective amount of the compound is in the form of an extract.

9 . The method of claim 8 , wherein the extract is an Oleaceae plant extract.

10 . The method of claim 5 , wherein the protein comprises whey protein.