Dendritic cell vaccination sequential to chemotherapy

1 . A method of treatment of ovarian cancer in a patient comprising administering to the patient a chemotherapy and a dendritic cell vaccine, wherein the chemotherapy consists of a combination treatment of paclitaxel and carboplatin and wherein the dendritic cell vaccine is administered to the patient after completion of the chemotherapy,

Wherein:

the dendritic cells are loaded ex vivo with whole ovarian tumor cells killed by high hydrostatic pressure,

from 5 to 30 doses of dendritic cell vaccines are administered, and

the cancer is Stage II-IV newly diagnosed ovarian cancer prior to the administration of first dose of the chemotherapy,

wherein the first dose of the dendritic cell vaccine is administered within two months after administration of last dose of the chemotherapy.

2 . The method of claim 1 , wherein the first dose of the dendritic cell vaccine is administered within one month after administration of the last dose of the chemotherapy.

3 . The method of claim 1 , wherein the dendritic cell vaccine is administered in combination with a maintenance therapy.

4 . The method of claim 1 , wherein the whole ovarian tumor cells are allogeneic to the patient or originate from one or multiple ovarian tumor cell lines.

5 . The method of claim 1 , wherein the dendritic cells are obtained from monocytes cultivated in the presence of cytokines, wherein the monocytes are obtained by leukapheresis prior to the chemotherapy.

6 . The method of claim 1 , wherein

i) the dendritic cell vaccine doses are administered at 1-week intervals, at 2-week intervals, at 3-week intervals, at 5-week intervals or at 6-week intervals; and/or

ii) the dosing schedule of the dendritic cell vaccine comprises 5 initial doses administered at 3-week intervals followed by 5 doses at 3-week intervals or 6-week intervals.

7 . The method of claim 6 , wherein 8 to 15 doses of dendritic cell vaccines are administered.

8 . The method of claim 1 , wherein the first dose of the dendritic cell vaccine is administered within two weeks after administration of the last dose of the chemotherapy.