Topical preparations
A topical preparation for use in treating dermatological ailments is prepared from a mixture comprising salicylic acid or a salt thereof, zinc or a salt thereof, iodine or a salt thereof, and a pharmaceutically acceptable carrier vehicle. The preparation comprises any one or more of anti-inflammatory properties, keratolytic properties, anti-pruritic properties, anti-carcinogenic properties. Methods of treatment involving topical application of the preparation are also described.
1 . A topical preparation for dermatological application, the preparation prepared from a mixture comprising:
zinc oxide;
salicylic acid; and
iodine;
in a pharmaceutically acceptable carrier vehicle, wherein the mixture comprises salicylic acid in an amount of from 1 to 2% m/m, zinc oxide in an amount of from 5 to 15% m/m, and iodine in an amount of from 0.001 to 0.01% m/m, based on the total mass of the preparation, wherein the iodine is provided in the mixture as a solution in ethanol.
2 . The topical preparation according to claim 1 , wherein the preparation includes one or more of, zinc iodide, a zinc salicylic acid complex, a zinc iodo-salicylate, an ethyl salicylate, a zinc ethyl salicylate, and/or a zinc ethyl iodo-salicylate.
3 . The topical preparation according to claim 1 , wherein zinc is present in molar excess with respect to salicylic acid, wherein the molar ratio of zinc to salicylic acid is at least about 1.5:1 and at most 20:1.
4 . The topical preparation according to claim 1 , wherein salicylic acid is present in molar excess with respect to iodine.
5 . The topical preparation according to claim 1 , wherein the preparation includes one or more zinc (II) iodo-salicylate.
6 . The topical preparation according to claim 1 , wherein the preparation includes one or more of zinc salicylate, 3-iodo salicylic acid, 5-iodo salicylic acid, 3,5-di-iodo salicylic acid and/or 3, 4, 5-tri-iodo salicylic acid.
7 . The topical preparation according to claim 1 , wherein salicylic acid is provided at a concentration of 2% m/m, zinc oxide is provided at a concentration of 10% m/m, and iodine is provided at a concentration of 0.01% m/m.
8 . The topical preparation according to claim 1 , wherein the carrier vehicle comprises one or more of emulsifying ointment, aqueous cream, castor oil cream, shea butter, hydrogel, alginate hydrogel, liquid paraffin, white soft paraffin, 50/50 liquid paraffin/white soft paraffin or combinations thereof.
9 . The topical preparation according to claim 1 , wherein the preparation further comprises from 5% m/m to 40% m/m castor oil.
10 . The topical preparation for dermatological application according to claim 1 , which is in the form of a cream, ointment, paste, lotion, gel, wash, solution, powder or hydrogel.
11 . The topical preparation according to claim 1 , wherein the pH of the preparation is approximately 5.5 to 6.
12 . A method of preparing the topical preparation for dermatological application according to claim 1 , said method comprising:
(a) preparing a mixture of salicylic acid and zinc oxide;
(b) adding a pharmaceutically acceptable carrier vehicle to the salicylic acid/zinc oxide mixture;
(c) adding iodine provided as a solution in ethanol to the carrier vehicle/salicylic acid/zinc oxide mixture; and
(d) agitating the mixture of step (c) to provide a homogenized preparation.
13 . The method of claim 12 , wherein the salicylic acid/zinc oxide mixture of step (a) is prepared from salicylic acid powder and zinc oxide powder, and the mixture is milled prior to adding the carrier vehicle.
14 . A method of preparing the topical preparation for dermatological application according to claim 1 , said method comprising:
(a) adding iodine provided as a solution in ethanol to a pharmaceutically acceptable carrier vehicle at a temperature between about 40 to 60° C.;
(b) adding zinc oxide and salicylic acid to the iodine-containing carrier vehicle; and
(c) agitating the mixture of step (b) until homogenized.
15 . A method of treating a dermatological condition in a subject in need thereof, the method comprising administering to the subject the topical preparation of claim 1 .
16 . The method according to claim 15 , wherein the dermatological condition to be treated is selected from the group consisting of psoriasis, rosacea, SSRD, atopic dermatitis, and a skin wound.
17 . The method according to claim 15 , wherein the topical preparation is administered daily at a dose of 5 g to 50 g.
18 . The method according to claim 15 , wherein the topical preparation is administered to the skin of the subject.
19 . The method according to claim 15 , wherein the subject is a human or an animal.
20 . The method according to claim 15 , wherein the administering repels biting insects.
21 . The method according to claim 12 , further comprising adding an additional quantity of pharmaceutically acceptable carrier vehicle to the carrier vehicle/salicylic acid/zinc oxide mixture of step (c) prior to the agitating of step (d).
22 . The method according to claim 14 , further comprising adding an emulsifier to the mixture of step (b) prior to the agitating of step (c).