IP Library › Granted Patent US 12708651
Granted Patent B2
US 12708651 · App. 16/950,493 · Granted Aug 18, 2026

Methods and compositions using

Inventors: Gabriela Bergonzelli Degonda (Bussigny, CH); Tiago Alves Nunes (Bern, CH); Valerie Marquardt (Epalinges, CH); Jeroen Antonius Johannes Schmitt (Moudon, CH)
Assignee: Societe des Produits Nestle S.A.
A61K35/745A23L33/135A61P25/22A23V2002/00A23V2200/31A23V2200/3202A23V2200/3204A23V2200/322
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Quick Facts
Patent No.
US 12708651
App. No.
16/950,493
Granted
Aug 18, 2026
Kind
B2
Abstract

Compositions and methods use Bifidobacterium longum NCC3001 (ATCC BAA-999) to stabilize or improve mood, modulate excessive emotional distress, reduce anxiety, and/or reduce stress. In an embodiment, the composition can be administered daily for at least three weeks.

Claims (15)

1 . A method of stabilizing and/or improving a mood disorder, wherein the mood disorder is clinical depression or bipolar disorder, the method comprising administering to an individual in need thereof an edible composition comprising a therapeutically effective amount of Bifidobacterium longum ATCC BAA-999, wherein the stabilizing and/or improving the mood disorder is relative to a level before initiating administration of the edible composition.

2 . The method of claim 1 , further comprising identifying the individual as being in need of stabilized and/or improved mood before administering the edible composition to the individual.

3 . The method of claim 1 , wherein the edible composition further comprises an ingredient selected from the group consisting of a fat, a protein, a carbohydrate and combinations thereof.

4 . The method of claim 1 , wherein the edible composition further comprises a prebiotic.

5 . The method of claim 4 , wherein the prebiotic is selected from the group consisting of an oligosaccharide, a dietary fiber, and a combination thereof.

6 . The method of claim 1 , wherein the edible composition is administered to the individual each day of a time period that is at least three weeks.

7 . The method of claim 1 , wherein at least a portion of the B. longum ATCC BAA-999 is alive.

8 . The method of claim 7 , wherein the edible composition comprises 10 4 to 10 11 cfu of the B. longum ATCC BAA-999 per g of dry weight of the edible composition.

9 . The method of claim 7 , wherein the edible composition is administered to the individual in a daily dose comprising between 10 4 and 10 12 cfu of the B. longum ATCC BAA-999.

10 . The method of claim 9 , wherein the daily dose is administered to the individual each day of a time period that is at least three weeks.

11 . The method of claim 1 , wherein at least a portion of the B. longum ATCC BAA-999 is non-replicating cells.

12 . The method of claim 11 , wherein the edible composition comprises between 10 2 and 10 8 of the non-replicating cells of B. longum ATCC BAA-999 per g of dry weight of the edible composition.

13 . The method of claim 11 , wherein the edible composition is administered to the individual in a daily dose comprising between 10 4 and 10 10 of the non-replicating cells of B. longum ATCC BAA-999.

14 . The method of claim 13 , wherein the daily dose is administered to the individual each day of a time period that is at least three weeks.

15 . The method of claim 1 , wherein the edible composition consists of natural ingredients.