Botanicals as WNT/beta-catenin activators, molecular pathway regulators, tissue regenerators and health biomarker regulators
The present disclosure provides botanicals and/or biotin or analogs thereof, that proliferate or reduce stem cell populations and activate or attenuate Wat/β-Catenin signaling and thus treat or prevent diseases related to signal transduction. In particular, the disclosure provides Botanicals and Biotin or analogs thereof, that proliferate or reduce stem cell populations and activate or attenuate Wnt/β-Catenin signaling in tissues expressing WntlOB including, adipose, adrenal, artery, blood, bone marrow, brain, breast, cervix, colon, esophagus, heart, intestine, kidney, liver, lung, muscle, ovary, pituitary, prostate, skin, spleen, testis, thyroid, uterus and vagina. The present compositions and methods are particularly suited to growing and melanizing hair.
1 . A method for maintaining or increasing proliferation of dermal papilla stem cells, follicular unit density, total hairs per follicular unit, terminal hairs per follicular unit, anagen hairs per follicular unit, hair diameter, hair growth rate, follicle productivity, or scalp coverage comprising administering a composition comprising:
biotin
0.005% to 1.00%;
caffeine
0.0001% to 1.00%;
Chenopodium quinoa
0.1% to 2.00%;
Eclipta prostrata
0.01% to 4.00%;
Lupinus
0.01% to 6.00%;
Malus domestica
0.01% to 4.00%;
methylsulfonylmethane
0.005% to 2.00%;
Momordica charantia
0.01% to 6.00%;
Moringa olifiera
0.01% to 6.00%;
Ocimum basilicum
0.01% to 6.00%;
Pisum sativum
0.01% to 6.00%;
Rosmarinus officinalis
0.01% to 4.00%;
Scutellaria baicalensis
0.01% to 4.00%;
Vitamin E (α tocopherol)
0.005% to 2.00%; and
proanthocyanidin
0.01% to 4.00%.
2 . The method according to claim 1 , wherein the composition is a topical composition and further comprises a fragrance ingredient comprising one or more of Cedrus deodora, Juniperus virginiana, Matricaria chamomilla, Anthemis nobilis, Helichrysium angustifolia, Jasmine grandiflorum, Lavandula angustifolia, Mentha piperita, Citrus sinensis, Achillea millefolium, Citrus bergamia, Calendula , or Tea Tree.
3 . The method according to claim 1 , wherein the composition is a shampoo and comprises:
biotin
0.025%;
caffeine
0.0010%;
Chenopodium quinoa
0.50%;
Eclipta prostrata
0.03%;
Lupinus
1.00%;
Malus domestica
0.06%;
methylsulfonylmethane
0.8%;
Momordica charantia
0.05%;
Moringa olifiera
1.00%;
Rosmarinus officinalis
0.03%;
Scutellaria baicalensis
0.10%;
Vitamin E (α tocopherol)
0.2%; and
Ocimum basilicum
0.00%, and
Pisum sativum
0.00%
proanthocyanidin
0.19%.
4 . The method according to claim 1 , wherein the composition is a conditioner and comprises:
biotin
0.025%;
caffeine
0.0010%;
Chenopodium quinoa
0.50%;
Eclipta prostrata
0.15%;
Lupinus
2.50%;
Malus domestica
0.19%;
methylsulfonylmethane
0.8%;
Momordica charantia
0.10%;
Moringa olifiera
2.00%;
Rosmarinus officinalis
0.03%;
Scutellaria baicalensis
0.10%;
Vitamin E (α tocopherol)
0.4%; and
Ocimum basilicum
0.00%, and
Pisum sativum
0.00%
proanthocyanidin
0.56%.
5 . The method according to claim 1 , wherein the composition is a scalp or a skin cream and comprises:
biotin
0.025%;
caffeine
0.0010%;
Chenopodium quinoa
1.50%;
Eclipta prostrata
0.30%;
Lupinus
2.50%;
Malus domestica
0.25%;
methylsulfonylmethane
0.8%;
Momordica charantia
0.20%;
Moringa olifiera
2.00%;
Ocimum basilicum
2.00%;
Pisum sativum
4.00%;
Rosmarinus officinalis
0.30%;
Scutellaria baicalensis
0.17%;
Vitamin E (α tocopherol)
0.50%; and
proanthocyanidin
0.75%.