Use of hyaluronic acid or salt thereof and/or trehalose in stabilizing ergothioneine, and ergothioneine composition containing hyaluronic acid or salt thereof and/or trehalose
The present application provides a use of a hyaluronic acid or a salt thereof and/or trehalose in stabilizing ergothioneine, an additive for stabilizing ergothioneine, the additive containing the hyaluronic acid or the salt thereof and/or trehalose, and a composition, the composition containing ergothioneine, the hyaluronic acid or the salt thereof, and trehalose. Compared with other auxiliary materials, the hyaluronic acid or the salt thereof and trehalose provided by the present invention can obviously mitigate the damage of a high temperature to ergothioneine, thereby increasing the yield of an ergothioneine powder product. The composition obtained by the present invention has good antioxidant and anti-apoptotic effects. Moreover, the inhibitory and scavenging effects of a composition obtained by compounding the hyaluronic acid or the salt thereof and trehalose to be used as an auxiliary material on intracellular reactive oxygen species are obviously better than those of a composition obtained by using a single hyaluronic acid or a salt thereof or trehalose as an auxiliary material.
1 . An additive for stabilizing ergothioneine, wherein the additive consists of hyaluronic acid or a salt thereof and trehalose, wherein the mass ratio of the hyaluronic acid or a salt thereof to trehalose is 1:99 to 50:50, and wherein the molecular weight of the hyaluronic acid or a salt thereof is 3 KDa to 10 KDa.
2 . The additive according to claim 1 , wherein the mass ratio of the hyaluronic acid or a salt thereof to trehalose is 1:19 to 1:10.
3 . The additive according to claim 1 , wherein the additive is used as an auxiliary material for spray-drying treatment of ergothioneine fermentation broth.
4 . A composition, wherein the composition comprises ergothioneine and the additive according to claim 1 .
5 . A composition, wherein the composition comprises ergothioneine and the additive according to claim 2 .
6 . A composition, wherein the composition comprises ergothioneine and the additive according to claim 3 .
7 . A composition, wherein the composition comprises ergothioneine, hyaluronic acid or a salt thereof and trehalose, wherein in parts by weight, ergothioneine is 1 part by weight, hyaluronic acid or a salt thereof is 20 to 1000 parts by weight, and trehalose is 1000 to 1980 parts by weight, and
wherein the molecular weight of the hyaluronic acid or a salt thereof is 3 KDa to 10 KDa.
8 . The composition according to claim 7 , wherein in parts by weight, ergothioneine is 1 part by weight, hyaluronic acid or a salt thereof is 100 to 180 parts by weight, and trehalose is 1800 to 1900 parts by weight.
9 . The composition according to claim 7 , wherein the composition has an antioxidant effect.
10 . A method for improving the thermostability of ergothioneine, comprising contacting the ergothioneine with hyaluronic acid or a salt thereof and trehalose to improve the thermostability of the ergothioneine,
wherein the mass ratio of the hyaluronic acid or a salt thereof to trehalose is 1:99 to 50:50, and
wherein the molecular weight of the hyaluronic acid or a salt thereof is 3 KDa to 30 KDa 10 KDa.