Compositions and methods for inhibiting XDH expression
Oligonucleotides are provided herein that inhibit XDH expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with aberrant XDH expression.
1 . An siRNA comprising a first RNA oligonucleotide and a second RNA oligonucleotide, wherein the first RNA oligonucleotide consists of the sequence set forth in SEQ ID: 23, and the second RNA oligonucleotide consists of the sequence set forth in SEQ ID: 24.
2 . A pharmaceutical composition comprising the siRNA according to claim 1 and a pharmaceutically acceptable carrier, delivery agent or excipient.
3 . A method of treating gout in a subject in need thereof, the method comprising administering to the subject the siRNA of claim 1 .
4 . A method for reducing xanthine dehydrogenase (XDH) expression in a subject in need thereof, the method comprising administering to the subject the siRNA of claim 1 .
5 . A method for reducing XDH expression in a cell, the method comprising contacting the cell with the siRNA of claim 1 .