Veterinary treatment of ophthalmic disease in animals using topical tacrolimus
View Patent ↗A composition and method for veterinary treatment of ophthalmic immune-mediated inflammatory conditions in animals such as conjunctival disorders of the third eyelid, keratoconjunctivitis sicca (KCS), chronic superficial keratitis (CSK), feline eosinophilic keratoconjunctivitis, allergic conjunctivitis, blepharoconjunctivitis, ocular rosacea, viral conjunctivitis, uveitis and phacoanaphylactic endophthalmitis involves the topical administration of tacrolimus to the eye in a pharmaceutically acceptable lubricant vehicle. The composition of the invention includes about 0.00001% to 10.0% tacrolimus by weight in a pharmaceutically acceptable oil-based solution or ointment and may be administered to the third eyelid of an affected animal.
1. A method of treating pannus in canines having said disease and comprising the steps of:
a) providing a quantity of a composition consisting essentially of an effective amount of tacrolimus in a pharmaceutically acceptable non-aqueous lubricant vehicle; and
b) administering a quantity of said composition to the third eyelid of an affected canine.
2. The method as set forth in claim 1 , wherein:
a) said tacrolimus is present in a concentration of from about 0.00001% to about 10.0% by weight.
3. The method as set forth in claim 1 , wherein said lubricating vehicle is selected from the group consisting essentially of corn oil, olive oil, mineral oil, cottonseed oil, sesame oil, canola oil, peanut oil, safflower oil, sunflower oil, polyoxethylated castor oil, petrolatum, mineral oil or mixtures thereof.