IP Library › Granted Patent US 9,918,984
Granted Patent B2
US 9,918,984 · App. 15/088,539 · Granted Mar 20, 2018

Methods and compositions for treating diabetes, metabolic syndrome and other conditions

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Quick Facts
Patent No.
US 9,918,984
App. No.
15/088,539
Filed
Apr 1, 2016
Granted
Mar 20, 2018
Kind
B2
Art Unit
1627
USPC
514/183
Abstract

Pharmaceuticals compositions comprising the 2S, 4R, ketoconazole enantiomer or its pharmaceutically acceptable salts, hydrates, and solvates, that are substantially free of the 2R, 4S ketoconazole enantiomer are useful to reduce cortisol synthese and for the treatment of type 2 diabetes, hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other diseases and conditions, including but not limited to Cushing's Syndrome, depression, and glaucoma.

Claims (2)

1. A method for treating Cushing's Syndrome in a patient in need of such treatment, said method comprising administering a therapeutically effective amount of 2S,4R ketoconazole enantiomer substantially free of the 2R,4S ketoconazole enantiomer to said patient.

2. The method of claim 1 , wherein the therapeutically effective amount of the 2S,4R ketoconazole enantiomer is from about 50 mg to about 600 mg.