Method for prophylaxis or treatment of a nervous system, pathophysiological condition involving a glial growth factor sensitive cell by administration of a glial growth factor
View Patent ↗The invention involves prophylaxis or treatment of nervous system pathological conditions. This is accomplished by administering secretable glial growth factors, such as the molecule referred to as GGF-2.
1. A method for treating a subject suffering from a nervous system pathophysiological condition caused by demyelination, said method comprising administering to said subject an effective amount of a glial growth factor protein, said protein comprising an EGF-like domain selected from the group consisting of the amino acid sequence of SEQ ID NO: 237 or the amino acid sequence of SEQ ID NO: 238.
2. A method for treating a subject suffering from a nervous system pathophysiological condition caused by demyelination, said method comprising administering to said subject an effective amount of a glial growth factor protein, said protein comprising the amino acid sequence of SEQ ID NO: 230 or comprising the amino acid sequence of SEQ ID NO: 231.
3. The method of claim 1 , wherein said nervous system pathophysiological condition involves glia of the central nervous system.
4. The method of claim 1 , wherein said nervous system pathophysiological condition is selected from the group consisting of:
(1) demyelination of Schwann cells; and
(2) damage to Schwann cells.
5. The method of claim 2 , wherein said nervous system pathophysiological condition involves glia of the central nervous system.
6. The method of claim 2 , wherein said nervous system pathophysiological condition is selected from the group consisting of:
(1) demyelination of Schwann cells; and
(2) damage to Schwann cells.