Use of (R)-peniciclovir triphosphate for the manufacture of a medicament for the treatment of viral diseases
View Patent ↗A method of treatment of: i) HIV-1 infections in mammals, including humans; or ii) HBV infections in mammals, including humans; which method comprises the administration to the human in need of such treatment, an effective amount of the (R)-enantiomer of the triphosphate of a compound of formula (A) or a pharmaceutically acceptable salt thereof; and compounds for use in the method.
1. A method of treatment of
i) HIV-1 infections in mammals, including humans; or
ii) HBV infections in mammals, including humans;
which method comprises the administration to the human in need of such treatment, an effective amount of the (R)-enantiomer of the triphosphate of a compound of formula (A):
((R)-PCT-TP), or a pharmaceutically acceptable salt thereof:
wherein the (R)-PCV-TP is in the form of a bioprecursor which is a PL-ASOR derivative, phospholipids derivative, (R)-MP Bis(POM) derivative, (R)-MPT diphenyl ester derivative, or dimyristoylglycerol diphosphate derivative of (R)-PCV-MP which liberates intracellularly (R)-PCV-MP which is in turn converted to (R)-PCV-TP.
2. The method according to claim 1 wherein the bioprecursor is a PL-ASOR derivative.
3. The method according to claim 1 wherein the bioprecursor is a phospholipids derivative.
4. The method according to claim 1 wherein the bioprecursor is a (R)-MP Bis(POM) derivative.
5. The method according to claim 1 wherein the bioprecursor is a (R)-MP diphenyl ester derivative.
6. The method according to claim 1 wherein the bioprecursor is a dimyristoylglycerol disphosphate derivative.