5-androstene-3β, 17α diol as an inhibitor of tumor growth
View Patent ↗The instant application provides means of accelerating cell aging and programed cell death in tumor cells by administration of 3β,17α androstenediol (αAED) or its ethers or esters.
1. A composition of matter comprising a carrier and a tumor inhibiting effective amount of a compound selected from the group consisting of 5-androstene-3β,17α-diol and an ester or ether thereof of the formula:
wherein,
R independently are H, alkenyl of 2-8 carbons, alkyl of 1-8 carbons, phenylalkyl of 1-4 carbons, phenyl or COR 2 ,
R 2 independently are H, alkyl of 1-8 carbons, alkenyl of 2-8 carbons, phenylalkyl wherein the alkyl has 1-4 carbons or phenyl, wherein any phenyl moiety optionally has up to three substituents chosen from among hydroxy, carboxy of 1-4 carbons, halo, alkoxy of 1-4 carbons, alkyl of 1-4 carbons, or alkenyl of 2-4 carbons and wherein any alkyl optionally is a straight chain, branched chain, or the alkyl optionally is wholly or partially cyclized, wherein the composition is a formulation for oral, parenteral, buccal, sublingual, endotracheal or aerosol administration.
2. The composition of claim 1 wherein the compound is 5-androstene-3β,17α-diol.
3. The composition of claim 1 in the form of a tablet.
4. The composition of claim 1 in the form of a capsule.
5. A composition of matter comprising a cyclodextrin and a tumor inhibiting effective amount of a compound selected from the group consisting of 5-androstene-3β,17α-diol and an ester or ether thereof of the formula:
wherein,
R are selected from H, alkenyl of 2-8 carbons, alkyl of 1-8 carbons, phenylalkyl of 1-4 carbons, phenyl or COR 2 ,
R 2 are selected from H, alkyl of 1-8 carbons, alkenyl of 2-8 carbons, phenylalkyl wherein the alkyl has 1-4 carbons or phenyl, wherein any phenyl moiety optionally has up to three substituents chosen from among hydroxy, carboxy of 1-4 carbons, halo, alkoxy of 1-4 carbons, alkyl of 1-4 carbons, or alkenyl of 2-4 carbons and wherein any alkyl optionally is a straight chain, branched chain, or the alkyl optionally is wholly or partially cyclized, wherein said composition is a formulation for oral, parenteral, buccal, sublingual, endotracheal or aerosol administration.
6. The composition of claim 5 wherein the compound is 5-androstene-3β,17α-diol.
7. The composition of claim 5 in the form of a tablet or a capsule.
8. The composition of claim 5 in the form of a parenteral formulation.
9. The composition of claim 5 , wherein said composition is in a form selected from the group consisting of a spray, a cream, a jelly, a suppository, a douching solution, a liquid and an adhesive patch.