Granted Patent
B1
US 7,396,919 · App. 09/328,975 · Granted Jul 8, 2008
Charge reversal of polyion complexes
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Abstract
An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.
Claims (4)
1. A tertiary complex for delivering a nucleic acid to a cell in vivo, comprising:
a) the nucleic acid;
b) a polycation polymer complexed with the nucleic acid; and,
c) a polyanion polymer, having more than 80 monomer units, complexed with the polycation via ionic interaction, wherein the polyanion polymer is not the nucleic acid of a) and the polyanion and the polycation polymers comprise block co-polymers.
Assignments (3)
CHANGE OF NAME
Recorded Apr 6, 2009
From: MIRUS BIO CORPORATION
To: ROCHE MADISON INC.
Reel/Frame 022629/0791 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 19, 2008
From: WOLFF, JON A; HAGSTROM, JAMES E; TRUBETSKOY, VLADIMIR; MONAHAN, SEAN D; SLATTUM, PAUL M; BUDKER, TATYANA
To: MIRUS BIO CORPORATION
Reel/Frame 021547/0751 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 19, 2008
From: LOOMIS, AARON G
To: MIRUS BIO CORPORATION
Reel/Frame 021547/0814 →