Transdermal delivery system
View Patent ↗The present invention relates to the discovery of a transdermal delivery system that can deliver high molecular weight pharmaceuticals and cosmetic agents to skin cells. A novel transdermal delivery system with therapeutic and cosmetic application and methods of use of the foregoing is disclosed.
1. A transdermal delivery system comprising:
an ethoxylated oil selected from the group consisting of ethoxylated castor oil, ethoxylated jojoba oil, ethoxylated corn oil, and ethoxylated emu oil;
an alcohol mixed with the ethoxylated oil so as to form a penetration enhancer;
an aqueous adjuvant mixed with the penetration enhancer, wherein the aqueous adjuvant comprises Aloe Vera ; and
a delivered agent mixed with the aqueous adjuvant and the penetration enhancer.
2. The transdermal delivery system of claim 1 , wherein the ethoxylated oil has at least 20 ethoxylations per molecule.
3. The transdermal delivery system of claim 1 , wherein about 0.1% to 40.0% by weight or volume is ethoxylated oil.
4. The transdermal delivery system of claim 1 , wherein about 0.1% to 15% by weight or volume is alcohol.
5. The transdermal delivery system of claim 1 , wherein about 0.1% to 85% by weight or volume is Aloe Vera.
6. The transdermal delivery system of claim 1 , wherein the ratio of ethoxylated oil:alcohol:aqueous adjuvant is selected from the group consisting of 1:1:4, 1:1:14, 3:4:3, and 1:10:25.
7. The transdermal delivery system of claim 1 , wherein the delivered agent is a molecule having a molecular weight of less than 6,000 daltons.
8. The transdermal delivery system of claim 1 , wherein the delivered agent is a molecule having a molecular weight of greater than 6,000 daltons.
9. The transdermal delivery system of claim 1 , wherein the delivered agent is selected from the group consisting of capsaicin, Boswellin, non steroidal anti-inflammatory drug, and collagen.
10. An apparatus comprising a vessel joined to an applicator and the transdermal delivery system of claim 1 incorporated in the vessel.
11. The apparatus of claim 10 , wherein the applicator is a roll-on or a sprayer.
12. A transdermal delivery system comprising:
an ethoxylated oil selected from the group consisting of ethoxylated castor oil, ethoxylated jojoba oil, ethoxylated corn oil, and ethoxylated emu oil;
an alcohol mixed with the ethoxylated oil so as to form a penetration enhancer;
Aloe Vera mixed with the penetration enhancer; and
a therapeutically effective amount of capsaicin or NSAID or both mixed with the penetration enhancer and Aloe Vera.
13. The transdermal delivery system of claim 12 , wherein the therapeutically effective amount of capsaicin is by weight or volume 0.01% to 13%.
14. The transdermal delivery system of claim 12 , further comprising by weight or volume 0.1% to 10% Boswellin.
15. An apparatus comprising a vessel joined to an applicator and the transdermal delivery system of claim 12 incorporated in the vessel.
16. The apparatus of claim 15 , wherein the applicator is a roll-on or a sprayer.
17. A transdermal delivery system comprising:
an ethoxylated oil selected from the group consisting of ethoxylated castor oil, ethoxylated jojoba oil, ethoxylated corn oil, and ethoxylated emu oil;
an alcohol mixed with the ethoxylated oil so as to form a penetration enhancer;
an aqueous adjuvant mixed with the penetration enhancer, wherein the aqueous adjuvant comprises Aloe Vera ; and
a therapeutically effective amount of a delivered agent of less than or equal to 2,000,000 daltons mixed with the penetration enhancer and aqueous adjuvant.
18. The transdermal delivery system of claim 17 , wherein the delivered agent is a collagen or fragment thereof.
19. The transdermal delivery system of claim 18 , wherein the collagen has an approximate average molecular weight from about 2,000 daltons to about 500,000 daltons.
20. The transdermal delivery system of claim 18 , wherein the therapeutically effective amount of collagen by weight or volume is 0.1% to 50.0%.
21. The transdermal delivery system of claim 18 , wherein the collagen has an approximate average molecular weight of about 2,000 daltons and the therapeutically effective amount by weight or volume is 0.1% to 50.0%.
22. The transdermal delivery system of claim 18 , wherein the collagen has an approximate average molecular weight of about 300,000 daltons and the therapeutically effective amount is 0.1% to 2.0%.
23. The transdermal delivery system of claim 18 , wherein the collagen has an approximate average molecular weight of about 500,000 daltons and the therapeutically effective amount by weight or volume is 0.1% to 4.0%.
24. An apparatus comprising a vessel joined to an applicator and the transdermal delivery system of claim 17 incorporated in the vessel.
25. The apparatus of claim 24 , wherein the applicator is a roll-on or a sprayer.
26. A method of making a transdermal delivery system comprising:
providing an ethoxylated oil selected from the group consisting of ethoxylated castor oil, ethoxylated jojoba oil, ethoxylated corn oil, and ethoxylated emu oil;
mixing the ethoxylated oil with an alcohol, nonionic solubilizer, or emulsifier so as to form a penetration enhancer;
mixing the penetration enhancer with an aqueous adjuvant, wherein the aqueous adjuvant comprises Aloe Vera ; and
mixing the penetration enhancer and aqueous adjuvant with a delivered agent and thereby making the transdermal delivery system.
27. The method of claim 26 , wherein the delivered agent is selected from the group consisting of capsaicin, Boswellin, non steroidal anti-inflammatory drug, and collagen.
28. The method of claim 26 , wherein the delivered agent is less than or equal to 2,000,000 daltons.
29. The method of claim 26 , further comprising incorporating the transdermal delivery system into an application device.
30. The method of claim 29 , wherein the application device has a roll-on applicator or a sprayer.
31. The transdermal delivery system of claim 1 , wherein the delivered agent is a non steroidal anti-inflammatory drug.
32. The transdermal delivery system of claim 31 , wherein the non steroidal anti-inflammatory drug is selected from the group consisting of naproxin, ibuprofen, and aspirin.
33. The transdermal delivery system of claim 31 , wherein the non steroidal anti-inflammatory drug is aspirin.
34. The transdermal delivery system of claim 1 , wherein the ethoxylated oil is ethoxylated castor oil.
35. The transdermal delivery system of claim 1 , wherein the ethoxylated oil is ethoxylated jojoba oil.
36. The transdermal delivery system of claim 1 , wherein the ethoxylated oil is ethoxylated corn oil.
37. The transdermal delivery system of claim 1 , wherein the ethoxylated oil is ethoxylated emu oil.
38. The method of claim 26 , wherein the ethoxylated oil is ethoxylated castor oil.
39. The method of claim 26 , wherein the ethoxylated oil is ethoxylated jojoba oil.
40. The method of claim 26 , wherein the ethoxylated oil is ethoxylated corn oil.
41. The method of claim 26 , wherein the ethoxylated oil is ethoxylated emu oil.
42. The composition of claim 1 , wherein the delivered agent is less than or equal to 2,000,000 daltons.
43. The composition of claim 1 , wherein the delivered agent is less than or equal to 1,500,000 daltons.
44. The composition of claim 1 , wherein the delivered agent is less than or equal to 1,000,000 daltons.
45. The composition of claim 1 , wherein the delivered agent is less than or equal to 700,000 daltons.
46. The composition of claim 1 , wherein the delivered agent is less than or equal to 500,000 daltons.
47. The composition of claim 1 , wherein the delivered agent is less than or equal to 300,000 daltons.
48. The composition of claim 1 , wherein the delivered agent is less than or equal to 200,000 daltons.
49. The composition of claim 1 , wherein the delivered agent is less than or equal to 100,000 daltons.
50. The composition of claim 1 , wherein the delivered agent is less than or equal to 75,000 daltons.
51. The composition of claim 1 , wherein the delivered agent is less than or equal to 50,000 daltons.
52. The composition of claim 1 , wherein the delivered agent is less than or equal to 25,000 daltons.
53. The composition of claim 1 , wherein the delivered agent is less than or equal to 20,000 daltons.
54. The composition of claim 1 , wherein the delivered agent is less than or equal to 15,000 daltons.
55. The composition of claim 1 , wherein the delivered agent is less than or equal to 10,000 daltons.
56. The composition of claim 1 , wherein the delivered agent is less than or equal to 5,000 daltons.
57. The composition of claim 1 , wherein the delivered agent is less than or equal to 2,500 daltons.
58. The composition of claim 1 , wherein the delivered agent is less than or equal to 1,000 daltons.
59. The composition of claim 17 , wherein the delivered agent is less than or equal to 1,500,000 daltons.
60. The composition of claim 17 , wherein the delivered agent is less than or equal to 1,000,000 daltons.
61. The composition of claim 17 , wherein the delivered agent is less than or equal to 700,000 daltons.
62. The composition of claim 17 , wherein the delivered agent is less than or equal to 500,000 daltons.
63. The composition of claim 17 , wherein the delivered agent is less than or equal to 300,000 daltons.
64. The composition of claim 17 , wherein the delivered agent is less than or equal to 200,000 daltons.
65. The composition of claim 17 , wherein the delivered agent is less than or equal to 100,000 daltons.
66. The composition of claim 17 , wherein the delivered agent is less than or equal to 75,000 daltons.
67. The composition of claim 17 , wherein the delivered agent is less than or equal to 50,000 daltons.
68. The composition of claim 17 , wherein the delivered agent is less than or equal to 25,000 daltons.
69. The composition of claim 17 , wherein the delivered agent is less than or equal to0,000 daltons.
70. The composition of claim 17 , wherein the delivered agent is less than or equal to 15,000 daltons.
71. The composition of claim 17 , wherein the delivered agent is less than or equal to 10,000 daltons.
72. The composition of claim 17 , wherein the delivered agent is less than or equal to 5,000 daltons.
73. The composition of claim 17 , wherein the delivered agent is less than or equal to 2,500 daltons.
74. The composition of claim 17 , wherein the delivered agent is less than or equal to 1,000 daltons.
75. The method of claim 26 , wherein the delivered agent is less than or equal to 1,500,000 daltons.
76. The method of claim 26 , wherein the delivered agent is less than or equal to 1,000,000 daltons.
77. The method of claim 26 , wherein the delivered agent is less than or equal to 700,000 daltons.
78. The method of claims 26 , wherein the delivered agent is less than or equal to 500,000 daltons.
79. The method of claim 26 , wherein the delivered agent is less than or equal to 300,000 daltons.
80. The method of claim 26 , wherein the delivered agent is less than or equal to 200,000 daltons.
81. The method of claim 26 , wherein the delivered agent is less than or equal to 100,000 daltons.
82. The method of claim 26 , wherein the delivered agent is less than or equal to 75,000 daltons.
83. The method of claim 26 , wherein the delivered agent is less than or equal to 50,000 daltons.
84. The method of claim 26 , wherein the delivered agent is less than or equal to 25,000 daltons.
85. The method of claim 26 , wherein the delivered agent is less than or equal to 20,000 daltons.
86. The method of claim 26 , wherein the delivered agent is less than or equal to 15,000 daltons.
87. The method of claim 26 , wherein the delivered agent is less than or equal to 10,000 daltons.
88. The method of claim 26 , wherein the delivered agent is less than or equal to 5,000 daltons.
89. The method of claim 26 , wherein the delivered agent is less than or equal to 2,500 daltons.
90. The method of claim 26 , wherein the delivered agent is less than or equal to 1,000 daltons.