Rapidly Disintegrable solid preparation
View Patent ↗A rapidly disintegrable solid preparation which comprises (i) a pharmacologically active ingredient, (ii) a sugar and (iii) a low-substituted hydroxypropylcellulose having 5% by weight or more to less than 7% by weight of hydroxypropoxyl group. The rapidly disintegrable solid preparation has fast disintegrability, suitable strength and no roughness.
1. A method for preparing a rapidly disintegrable tablet comprising
producing fine granules containing lansoprazole, said granules having a core and at least one layer coating said core,
blending said fine granules with a sugar and a low-substituted hydroxypropylcellulose having 5% to less than 7% by weight of hydroxypropoxyl groups, said sugar is an amount of in an amount of 5 to 97 parts by weigh per 100 parts by weight of the rest of the tablet other than the fine granules and
molding to obtain a tablet,
wherein said tablet is bucally dissolved in from about 5 to about 50 seconds.
2. A method for improving fast disintegrability of a lansoprazole comprising
adding low-substituted hydroxypropylcellulose having 5% to less than 7% by weight of hydroxypropoxyl groups and sugar in combination with fine granules containing lansoprazole to obtain an improved tablet;
wherein said sugar is added in an amount of 5 to 97 parts by weight per 100 parts by weight of the rest of the tablet other than said fine granules, and
wherein said improved tablet is bucally dissolved in from about 5 to about 50 seconds.
3. The method of claim 1 , wherein said tablet is bucally dissolved in from about 5 to about 40 seconds.
4. The method of claim 1 , wherein said tablet is bucally dissolved in from about 5 to about 35 seconds.
5. The method of claim 1 , wherein said sugar is a sugar alcohol.
6. The method of claim 1 , wherein said sugar is mannitol or erythritol.
7. The method of claim 2 , wherein said tablet is bucally dissolved in from about 5 to about 40 seconds.
8. The method of claim 2 , wherein said tablet is bucally dissolved in from about 5 to about 35 seconds.
9. An orally disintegrabic tablet comprising:
fine granules containing lansoprazole, said granules having a core and at least one layer coating said core;
a sugar wherein said sugar is in an amount of 5 to 97 parts by weight of the rest of the tablet other than said fine granules; and
a low-substituted hydroxypropylcellulose having 5 to 7% by weight of hydroxypropoxyl groups;
wherein said low-substituted hydroxypropyl cellulose is separate from said fine granules in said tablet;
wherein said tablet is improved in chalky taste and has no roughness and wherein said tablet is bucally dissolved in from about 5 to about 50 seconds.
10. The tablet of claim 9 wherein said fine granules are enteric-coated fine granules.