Diagnostic agents and remedies for malignant tumors
View Patent ↗An agent for diagnosing or photokinetically treating malignant tumors, comprising as an active ingredient a compound in which at least one carbon atom of 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, or an ester, amide, salt, hydrate or solvate of the compound.
1. A method for detecting and treating a malignant tumor, which method comprises;
administering a tumor detecting effective amount, to a host in need of detection of a malignant tumor, of 5-aminolevulinic acid or a derivative thereof in which at least one carbon atom of said 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and where said derivative is an ester, amide, salt, hydrate or solvate of said 5-aminolevulinic acid;
detecting the malignant tumor using NMR; and
administering an effective amount of said 5-aminolevulinic acid or derivative thereof, in which at least one carbon atom of said 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and where said derivative is an ester, amide, salt, hydrate or solvate of said 5-aminolevulinic acid, to kill said malignant tumor.
2. The method of claim 1 wherein said 5-aminolevulinic acid or derivative thereof is used in combination with a diagnostically acceptable carrier.
3. A method for detecting and treating a malignant tumor, which method comprises;
administering a tumor detecting effective amount, to a host in need of detection of a malignant tumor, of a 5-aminolevulinic acid or a derivative thereof in which at least one carbon atom of said 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and where said derivative is an ester, amide, salt, hydrate or solvate of said 5-aminolevulinic acid to thereby accumulate the carbon isotope and/or the nitrogen isotope in the malignant tumor;
detecting the carbon and/or the nitrogen isotope using NMR to thereby identity the position of the malignant tumor; and
administering an effective amount of said 5-aminolevulinic acid or a derivative thereof,
in which at least one carbon atom of said 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and where said derivative is an ester, amide, salt, hydrate or solvate of said 5-aminolevulinic acid, to kill said malignant tumor.
4. The method of claim 3 , wherein the malignant tumor is detected and treated in a living host.
5. The method of claim 1 , wherein the killing of said malignant tumor is by a photokinetic method.
6. The method of claim 3 , wherein the killing of said malignant tumor is by a photokinetic method.
7. The method of claim 1 , wherein the carbon isotope is used and it is the 13 C or 14 C isotope.
8. The method of claim 7 , wherein the carbon isotope is used and it is the 13 C isotope and the NMR is 13 C-NMR.
9. The method of claim 3 , wherein the carbon isotope is used and it is the 13 C or 14 C isotope.
10. The method of claim 9 , wherein the carbon isotope is used and it is the 13 C isotope and the NMR is 13 C-NMR.
11. The method of claim 1 , wherein the nitrogen isotope is used and it is the 15 N isotope.
12. The method of claim 3 , wherein the nitrogen isotope is used and it is the 15 N isotope.
13. The method of claim 1 , wherein said derivative is used and said derivative is the ester.
14. The method of claim 3 , wherein said derivative is used and said derivative is the ester.
15. The method of claim 1 , wherein said derivative is used and said derivative is the amide.
16. The method of claim 3 , wherein said derivative is used and said derivative is the amide.
17. The method of claim 1 , wherein said derivative is used and said derivative is the salt.
18. The method of claim 3 , wherein said derivative is used and said derivative is the salt.
19. The method of claim 1 , wherein said derivative is used and said derivative is the hydrate.
20. The method of claim 3 , wherein said derivative is used and said derivative is the hydrate.
21. The method of claim 1 , wherein said derivative is used and said derivative is the solvate.
22. The method of claim 3 , wherein said derivative is used and said derivative is the solvate.
23. The method of claim 1 , wherein the detecting and treating are conducted using a total dose of from 10 mg to 10 g per kg body weight.
24. The method of claim 3 , wherein the detecting and treating are conducted using a total dose of from 10 mg to 10 g per kg body weight.
25. The method of claim 1 , wherein the detecting and treating are performed with the same 5-aminolevulinic acid or a derivative thereof in which at least one carbon atom of said 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and wherein said derivative is an ester, amide, salt, hydrate or solvate of said 5-aminolevulinic acid.
26. The method of claim 3 , wherein the detecting and treating are performed with the same 5-aminolevulinic acid or a derivative thereof in which at least one carbon atom of said 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and wherein said derivative is an ester, amide, salt, hydrate or solvate of said 5-aminolevulinic acid.
27. The method of claim 1 , wherein said malignant tumor exists in a deep region of tissue.
28. The method of claim 3 , wherein said malignant tumor exists in a deep region of tissue.
29. The method of claim 1 , wherein the malignant tumor is detected and treated in a living host.