Pharmaceutical compositions and utilization thereof particularly for the treatment of neurodegenerative disorders
View Patent ↗The present invention relates to pharmaceutical compositions that act on the p53 protein or its gene and methods of use for the treatment of neurodegenerative diseases.
1. A recombinant virus selected from the group consisting of adenovirus, adeno-associated virus and herpes virus, said recombinant virus comprising a nucleic acid consisting of:
(a) nucleic acids consisting of the sequence of SEQ ID NO:1 encoding an antisense RNA which inhibits expression of p53.
2. A method of inhibiting glutamate mediated ischemic neuronal cell death in cultured neuronal cells comprising: (a) administering to said cells a nucleic acid encoding an antisense RNA which inhibits expression of p53 wherein said nucleic acid has the sequence of SEQ ID NO: 1.
3. The method of claim 2 , wherein the nucleic acid is within a vector.
4. The method of claim 3 , wherein the vector is a replication defective virus.