Granted Patent
B1
US 7,186,553 · App. 09/673,958 · Granted Mar 6, 2007
Human derived immortalized liver cell line
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Abstract
The present invention relates to a new immortalized hepatocyte culture of human (preferably human fetal) normal cell origin. The immortalized hepatocyte culture of human normal cell origin of the present invention is useful in, for example, screening for compounds or salts thereof having therapeutic/preventive effects on hepatic insufficiency.
Claims (1)
1. An immortalized hepatocyte cell culture of human normal cell origin retaining CYPIA1, CYPIA2 and CYP3A enzyme activity involved in the metabolism of xenobiotics in the liver or which can be induced to express genes encoding enzymes involved in the metabolism of xenobiotics in the liver, wherein said enzymes are CYPIA1, CYPIA2 and CYP3A wherein the cell culture is FERM BP-6328.
Assignments (3)
CHANGE OF NAME
Recorded Jun 2, 2005
From: TAKEDA CHEMICAL INDUSTRIES, LTD.
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 018917/0406 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 21, 2001
From: ASAHI, SATORU; YOSHITOMI, SUMIE
To: TAKEDA CHEMICAL INDUSTRIES, LTD.
Reel/Frame 011972/0275 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 21, 2001
From: FUKAYA, KENICHI
To: TAKEDA CHEMICAL INDUSTRIES, LTD.
Reel/Frame 011972/0298 →