Method and apparatus for displaying gene expression patterns
View Patent ↗The present invention discloses a method for displaying gene expression patterns of multiple genes that change according to the experiment cases, where a first axis represents the genes and a second axis represents the experiment cases. The method comprises two steps. The first step consists of designating a segment along the second axis in the expression pattern data of the multiple genes. The second step comprises clustering the expression pattern data within the designated segment along the second axis based on a predetermined reference value, repeating clustering within the same cluster in a forward or reverse direction along the second axis while changing the reference value, and displaying the results according to a predetermined display format.
1. A method for displaying gene expression patterns of multiple genes whose expressions change according to experiment cases, where a first axis represents the genes and a second axis represents gene expression status of the experiment cases, the method comprising the steps of:
designating a clustering-applied region along the second axis and a segment shorter than a width of the clustering-applied region along the second axis;
incrementally clustering the expression pattern data by the segment within the clustering-applied region in a forward or reverse direction along the second axis by calculating similarity or dissimilarity for clustering within a clustering range as wide as the segment along the second axis based on a respective reference value set for each clustering range; and
displaying the results according to a predetermined display format.
2. A method for displaying gene expression patterns according to claim 1 , further comprising comparing a plurality of expression patterns of every two different genes to determine whether said genes are identical or not.
3. A method for displaying gene expression patterns according to claim 2 :
wherein some of the multiple genes have the same expression pattern at the beginning of said experiment cases but change to different expression patterns within the clustering-applied region along the second axis.
4. A method for displaying gene expression patterns according to claim 2 :
wherein some of the multiple genes have different expression patterns at the beginning of said experiment case but change to the same expression pattern within the clustering-applied region along the second axis.
5. A method for displaying gene expression patterns according to claim 1 , wherein some of the multiple genes have the same expression pattern at the beginning of said experiment cases but change to different expression patterns within the clustering-applied region along the second axis.
6. A method for displaying gene expression patterns according to claim 1 , wherein some of the multiple genes have different expression patterns at the beginning of said experiment case but change to the same expression pattern within the clustering-applied region along the second axis.
7. A method for displaying gene expression patterns according to claim 1 , wherein the experiment cases are conducted in a time sequence.
8. A method for displaying gene expression patterns according to claim 1 , wherein the experiment cases are states of an individual's tissue.
9. A method for displaying gene expression pattern according to claim 1 , wherein the experiment cases are species of individuals.
10. A method for displaying gene expression pattern according to claim 1 , wherein the experiment cases are before and after drug administration.
11. An apparatus for analyzing gene expression patterns, which acquires, from a database, expression pattern data of multiple genes whose expressions change according to experiment cases, where a first axis represents the genes and a second axis represents gene expression status of the experiment cases, the apparatus comprising:
an inputting means for designating a clustering-applied region along the second axis and a segment shorter than a width of the clustering-applied region along the second axis obtained from the database, and an arithmetic unit for incrementally clustering the expression pattern data by the segment within the clustering-applied region in a forward or reverse direction along the second axis by calculating similarity or dissimilarity for clustering within a clustering range as wide as the segment along the second axis based on a respective reference value set for each clustering range; and
a display means for displaying the results according to a predetermined display format.