Fat-binding polymers
View Patent ↗The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.
1. A method of treating obesity in a mammal comprising the step of orally administering to the mammal an effective amount of at least one lipase inhibitor and a fat binding polymer, salt, or copolymer thereof, characterized by a repeat unit having the formula:
wherein R5=H, or an alkyl chain from C 1 to C 22 .
2. The method of claim 1 wherein R5=CH 3 .
3. The method of claim 1 wherein said polymer is Poly(N,N-diallyl-N-methyl-N-(2,3-dihydroxypropyl) ammonium chloride).
4. The method of claim 3 wherein said lipase inhibitor is tetrahydrolipstatin.
5. A method for treating steatorrhea in a mammal comprising the step of orally administering to the mammal a therapeutic amount of a polymer characterized by having a repeat unit having the formula:
wherein R5=H, or an alkyl chain from C 1 to C 22 .
6. A method for treating hypertriglyceridemia in a mammal comprising the step of administering to the mammal a therapeutically effective amount of at least one lipase inhibitor and a polymer characterized by a combination of repeat units having the formula
Wherein R5=H, or an alkyl chain from C 1 to C 22, in combination with at least one lipase inhibitor.
7. A method for reducing the absorption of dietary fat in a mammal comprising the step of orally administering to the mammal a therapeutically effective amount of at least one lipase inhibitor in combination with a polymer characterized by a combination of repeat units having the formula
Wherein R5=H, or an alkyl chain from C 1 to C 22 .
8. A method of treating obesity in a mammal comprising the step of orally administering to a mammal an effective amount of a polymer, salt, or copolymer thereof, characterized by a repeat unit having the formula:
in combination with at least one lipase inhibitor.
9. The method of claim 8 wherein said lipase inhibitor is tetrahydrolipstatin.
10. A method for treating steatorrhea in a mammal comprising the step of orally administering to the mammal a therapeutic amount of a polymer characterized by having a repeat unit having the formula:
11. A method for treating hypertriglyceridemia in a mammal comprising the step of administering to the mammal a therapeutically effective amount of at least one lipase inhibitor and a polymer characterized by a combination of repeat units having the formula:
12. A method for reducing the absorption of dietary fat in a mammal comprising the step of orally administering to the mammal a therapeutically effective amount of at least one lipase inhibitor and a polymer characterized by a combination of repeat units having the formula:
13. The method of claim 8 wherein said polymer is as Poly(N,N-diallyl-N,N-di(2,3-dihydroxypropyl)ammonium chloride).