Cholesterol lowering supplement
View Patent ↗The invention provides a composition and a method for lowering blood serum cholesterol levels or for preventing elevated blood serum cholesterol levels, as well as suitable composition comprising (a) one or more phytosterols and/orphytostanols or a mixture thereof capable of reducing cholesterol absorption in the intestine, (b) a composition capable of inhibiting cholesterol biosynthesis, and (c) a composition capable of increasing cholesterol metabolism, wherein at least one of compositions b. and c. is preferably derived from plants.
1. A composition comprising:
a. one or more phytosterols and/or phytostanols or a mixture thereof capable of reducing cholesterol absorption in the intestine;
b. a composition capable of inhibiting cholesterol biosynthesis;
c. a composition capable of increasing cholesterol metabolism,
wherein at least one of compositions b. and c. is derived from plants.
2. A composition according to claim 1 , wherein the at least one of compositions b. and c. is an extract from a plant or plant parts.
3. A composition according to claim 2 , wherein compositions b. and c. are extracts from different plants or parts thereof.
4. A composition according to claim 1 , wherein composition b. capable of inhibiting cholesterol biosynthesis comprises one or more HMG-CoA reductase inhibitors and/or squalene synthase inhibitors.
5. A composition according to claim 4 , wherein the composition capable of inhibiting cholesterol biosynthesis comprises one or more NMG-CoA reductase inhibitors.
6. A composition according to claim 4 , wherein the composition capable of inhibiting cholesterol biosynthesis is derived from a plant or plant part selected from the group consisting of Alisma orientale, Typha spp., Salvia miltiorhiza, Polygonum multiflorum, Curcuma spp., Ligusticum spp., Polygonun spp., Polygonun cuspidatum; Corydalis spp; Chrysanthemum morifolium; Arthemisia capillaris; Crataegus pinnatifida, Eleutheroccus senticocus, Astragalus membranaceus and subspecies or varieties thereof.
7. A composition according to claim 6 , wherein the composition capable of inhibiting cholesterol biosynthesis is an aqueous extract of Polygonum multiflorum.
8. A composition according to claim 1 , wherein composition a. contains at least 25% by weight of phytosterols and/or phytostanols.
9. A composition according to claim 1 , wherein the phytosterol and/or phytostanol or mixture thereof comprises a plant sterol obtained from vegetable oil or wood pulp.
10. A composition according to claim 9 , comprising a phytosterol selected from the group consisting of sitosterol, stigmasterol, ergosterol, campesterol, avenasterol, brassicasterol, desmosterol, chalinosterol, poriferasterol, clionasterol, sitostanol, stigmastanol and campestanol.
11. A composition according to claim 1 , wherein composition c. capable of increasing cholesterol metabolism comprises an effective amount of a composition capable of increasing conversion of cholesterol into bile acids and/or inhibiting the esterification of cholesterol.
12. A composition according to claim 11 , wherein composition c. comprises one or more cholesterol 7a-hydroxylase activators and/or one or more Acyl-CoA acyl transferase inhibitors.
13. A composition according to claim 12 , wherein the composition capable of increasing cholesterol metabolism is derived from a plant or plant part selected from the group consisting of Polygonum multiflorum, Polygonum cuspidatum, Curcuma spp., Ligusticum spp., Polygonatum spp., Corydalis spp., Chrysanthemum morifolium, Arthemisia capillaris and Acanthopanax senticosus.
14. A composition according to claim 13 , wherein the composition comprising an effective amount of a composition capable of increasing cholesterol metabolism is an aqueous extract of Chrysanthemum morifolium.
15. A food or beverage product comprising a composition according to claim 1 .
16. A nutritional supplement comprising a composition according to claim 1 .
17. A tablet, capsule, microbead, emulsion, powder, granule, suspension, syrup, elixir or chewing gum comprising a composition according to claim 1 .
18. A composition according to claim 1 , further comprising a component selected from the group consisting of poly-unsaturated fatty acids, antioxidants, phospholipids, folic acid, vitamin B12, vitamin B6, magnesium, coenzyme Q10 and zinc.
19. A composition according to claim 18 , wherein the polyunsaturated fatty acids comprise omega-6-fatty acids and/or omega-3-fatty acids.
20. A composition according to claim 18 , wherein the phospholipids comprise lecithin.
21. A composition according to claim 18 , wherein the antioxidants comprise tocopherols.
22. A composition according to claim 21 , wherein the tocopherols comprise vitamin E.
23. A method of reducing serum cholesterol levels or inhibiting elevated blood serum cholesterol levels comprising administering to a person in need thereof an effective amount of a composition comprising:
a. one or more phytosterols and/or phytostanols or a mixture thereof capable of reducing cholesterol absorption in the intestine;
b. a plant-derived composition capable of inhibiting cholesterol biosynthesis; and
c. a plant-derived composition capable of increasing cholesterol metabolism.