Use of a methylol-containing compound to treat tumors
View Patent ↗The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing methylol-containing compound. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.
1. A method of inducing apoptotic death of a neoplastic cell, comprising contacting said cell with an apoptosis-inducing amount of a methylol-containing compound, wherein said neoplastic cell is a carcinoma cell and wherein said compound is taurolidine or a derivative thereof and wherein said neoplastic cell is a metastasis from a non-CNS primary tumor.
2. A method of inducing apoptotic death of a neoplastic cell, comprising contacting said cell with an apoptosis-inducing amount of a methylol-containing compound, wherein said neoplastic cell is a carcinoma cell and wherein said compound is taurolidine or a derivative thereof and wherein said neoplastic cell is a multiple drug resistant tumor cell.
3. A method of inducing apoptotic death of a neoplastic cell, comprising contacting said cell with an apoptosis-inducing amount of a methylol-containing compound, wherein said neoplastic cell is a carcinoma cell and wherein said compound is taurolidine or a derivative and wherein said neoplastic cell is an ovarian carcinoma cell.