IP Library › Granted Patent US 7,034,121
Granted Patent B2
US 7,034,121 · App. 09/772,103 · Granted Apr 25, 2006

Antibodies against CTLA4

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,034,121
App. No.
09/772,103
Granted
Apr 25, 2006
Kind
B2
Abstract

The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and is only expressed transiently on T cells upon T cell activation. Preferably, the T cell molecule is CTLA4. The invention further provides anti-CTLA4 antibodies and humanized forms thereof.

Claims (2)

1. A humanized antibody that is specifically reactive with human CTLA4, wherein the antibody comprises the amino acid sequence shown in SEQ ID NO: 8.

2. A humanized antibody that is specifically reactive with human CTLA4, wherein the antibody comprises the amino acid sequence shown in SEQ ID NO: 10.

Assignments (2)
CHANGE OF NAME Recorded Mar 1, 2006
From: GENETICS INSTITUTE, INC.
To: GENETICS INSTITUTE, LLC
Reel/Frame 017303/0157 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 10, 2006
From: PROTEIN DESIGN LABS, INC.
To: GENETICS INSTITUTE, INC.
Reel/Frame 017175/0625 →