Compound containing a labile disulfide bond
View Patent ↗A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal.
1. A compound for delivering a molecule from outside a mammalian cell to inside said mammalian cell comprising: said molecule covalently linked to a transduction signal via an activated disulfide bond that is cleaved more rapidly than oxidized glutathione wherein said transduction signal transports said molecule across a membrane of said cell, wherein said disulfide bond is cleaved in said cell and wherein said molecule remains in said cell after two hours.
2. The compound of claim 1 wherein the transduction signal consists of a peptide with sequence substantially identical to SEQ ID 1.
3. The compound of claim 1 wherein the transduction signal consists of VP22.
4. The compound of claim 1 wherein the transduction signal consists of ANTP.
5. The compound of claim 1 wherein the transduction signal consists of a polymer containing a cationic charge.
6. The compound of claim 5 wherein the transduction signal consists of a peptide containing cationic residues.
7. The compound of claim 1 wherein said molecule is associated with a nucleic acid.