Isolated nucleic acid molecules encoding human drug metabolizing proteins
View Patent ↗The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
1. A nucleic acid vector comprising the nucleic acid molecule of SEQ ID NO: 1 or SEQ ID NO: 3.
2. A host cell containing the vector of claim 1 .
3. A process for producing a polypeptide comprising SEQ ID NO: 2, the process comprising culturing the host cell of claim 2 under conditions sufficient for the production of said polypeptide, and recovering said polypeptide from the host cell.
4. An isolated polynucleotide consisting of a nucleotide sequence set forth in SEQ ID NO: 1.
5. An isolated polynucleotide consisting of a nucleotide sequence set forth in SEQ ID NO: 3.
6. A vector according to claim 1 , wherein said vector is selected from the group consisting of a plasmid, virus, and bacteriophage.
7. A vector according to claim 1 , wherein said isolated nucleic acid molecule is inserted into said vector in proper orientation and correct reading frame such that the protein of SEQ ID NO: 2 may be expressed by a cell transformed with said vector.
8. A vector according to claim 7 , wherein said isolated nucleic acid molecule is operatively linked to a promoter sequence.
9. An isolated nucleic acid molecule consisting of a nucleotide sequence that is completely complementary to a nucleotide sequence consisting of SEQ ID NO: 1 or SEQ ID NO: 3.
10. An isolated polynucleotide comprising a nucleotide sequence set forth in SEQ ID NO: 1.
11. An isolated polynucleotide comprising a nucleotide sequence set forth in SEQ ID NO: 3.
12. An isolated nucleic acid molecule consisting of a nucleotide sequence that is completely complementary to a nucleotide sequence comprising SEQ ID NO: 1 or SEQ ID NO: 3.