IP Library › Granted Patent US 7,012,079
Granted Patent B1
US 7,012,079 · App. 09/806,952 · Granted Mar 14, 2006

Optically pure camptothecin analogues

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Quick Facts
Patent No.
US 7,012,079
App. No.
09/806,952
Filed
Apr 5, 2001
Granted
Mar 14, 2006
Kind
B1
Art Unit
1625
USPC
514/279
Abstract

The invention relates in particular to the compounds of general formula in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 represent various radicals; their use as medicaments and pharmaceutical compositions containing them. These compounds are particularly useful for the treatment of cancer.

Claims (4)

1. A compound which is

(5R)-5-ethyl-9,10,difluoro-5-hydroxy-12-(2-trimethylsilylethyl)-4,5,13,15-tetrahydro-1H,3H-oxepino[3′,4′:6,7]-indoloizino[1,2-b]quinoleine-3,15-dione.

2. A pharmaceutical composition comprising an antitumorally effective amount of a compound of formula (II A ) of claim 1 and an inert carrier.

3. A method of treating colon cancer in warm-blooded animals comprising administering to warm-blooded animals in need thereof an effective amount of a compound of claim 1 to treat colon cancer.

Assignments (1)
CHANGE OF NAME Recorded Feb 11, 2009
From: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES
To: IPSEN PHARMA S.A.S.
Reel/Frame 022240/0147 →