Composition for creating vascular occlusions
View Patent ↗A composition including 2-hexyl cyanoacrylate and goal is useful in treating arteriovenous malformations (AVMs) and other body lumens to be blocked.
1. A composition for creating therapeutic vascular occlusions in an animal comprising a mixture of:
(a) Part 1 comprised of 2-hexyl cyanoacrylate, hydroquinone, p-methoxyphenol and phosphoric acid; and
(b) Part 2 comprising gold metal powder, ethyl myristate and a sterilized a large chain fatty acid ester in liquid form and a stabilized polymer of 2-hexylcyanoacrylate in weak aqueous bicarbonate solution .
2. The composition of claim 1 wherein Part 1 comprises about 100 PPM hydroquinone, 100 PPM p-methoxyphenol, 250 PPM phosphoric acid and the remainder 2-hexyl cyanoacrylate.
3. The composition of claim 2 wherein Part 2 comprises about 65 percent by weight gold, about 30 percent by weight ethyl myristate and the remainder said sterilized stabilized polymer of 2-hexylcyanoacrylate in weak aqueous bicarbonate solut ion .
4. The composition of claim 1 wherein Part 2 includes sulfur dioxide as a stabilizer.
5. A method for creating therapeutic vascular occlusions in an animal needing therapeutic vascular occlusion comprising the steps of:
(a) Mixing together Part 1 comprised of 2-hexyl cyanoacrylate, hydroquinone, p-methoxyphenol and phosphoric acid with Part 2 comprising gold metal powder, ethyl myristate and a sterilized a large chain fatty acid ester in liquid form, and a stabilized polymer of 2-hexylcyanoacrylate in weak aqueous bicarbonate solution ; and
(b) injecting administrating the mixture into a vascular site needing occlusion with the gold metal powder suspended in the mixture .