IP Library › Granted Patent US 6,923,962
Granted Patent B2
US 6,923,962 · App. 09/833,017 · Granted Aug 2, 2005

Signal peptides, nucleic acid molecules and methods for treatment of caries

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Quick Facts
Patent No.
US 6,923,962
App. No.
09/833,017
Granted
Aug 2, 2005
Kind
B2
Abstract

The invention relates to a compound that competitively inhibits binding of CSP to S. mutans histidine kinase. The compound is preferably a peptide or an antibody. The compound is preferably a derivative of [SEQ ID NO:2], a fragment of [SEQ ID NO:2] or a derivative of a fragment of [SEQ ID NO:2].

Claims (4)

1. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4 and having S. mutans competence signal peptide activity.

2. An isolated recombinant polypeptide comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4 which has S. mutans competence signal peptide activity.

3. A synthetic polypeptide comprising the 21-amino acid sequence of SEQ ID NO:4 having competence signal peptide activity.

4. An isolated S. mutans polypeptide comprising the amino acid sequence of SEQ ID NO: 4 which has competence signal peptide activity.

Assignments (2)
SECURITY INTEREST Recorded Nov 9, 2020
From: KANE BIOTECH INC.
To: PIVOT FINANCIAL INC.
Reel/Frame 054307/0264 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 9, 2006
From: CVITKOVITCH, DENNIS; LEVESQUE, CELINE; HUANG, CATHY YI-CHEN
To: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Reel/Frame 018362/0501 →