Methods and compositions useful in enhancing oxygen delivery to cells
View Patent ↗The invention discloses compositions and methods which are useful in improving delivery of oxygen to cells. The compositions require at least one derivative of a compound. The derivatives are chosen to have log P values below about 6.0.
1. A method for enhancing delivery of oxygen to a tissue, comprising administering to said tissue a nicotinic acid alkyl ester containing composition, wherein the alkyl group of said nicotinic acid alkyl ester consists of from 8 to 10 carbon atoms, wherein said composition contains from about 0.05% to about 5.0% by weight of said compound, in an amount sufficient to enhance oxygen delivery to said tissue.
2. The method of claim 1 , wherein said nicotinic acid alkyl ester is applied topically.
3. The method of claim 1 , wherein said tissue is skin.
4. The method of claim 1 , wherein said nicotinic acid alkyl ester is nicotinic acid octyl ester.
5. The method of claim 1 , wherein said composition contains from about 0.1% to about 1% by weight of said compound.
6. The method of claim 1 , wherein said composition is a cream, a lotion, a salve, a balm, a roll-on stick, a wash, or a suppository.
7. The method of claim 1 , wherein said composition further comprises butyl benzoate in an amount sufficient to modulate oxygenation by inhibiting conversion of said nicotinic acid alkyl ester to nicotinic acid.
8. The method of claim 1 , wherein said alkyl group of said nicotinic acid alkyl ester consists of 8 carbon atoms.
9. The method of claim 1 , wherein said alkyl group of said nicotinic acid alkyl ester consists of 9 carbon atoms.
10. The method of claim 1 , wherein said alkyl group of said nicotinic acid alkyl ester consists of 10 carbon atoms.
11. The method of claim 1 , wherein said composition enhances delivery of oxygen for at least 4 hours.