IP Library › Granted Patent US 6,890,512
Granted Patent B2
US 6,890,512 · App. 09/836,625 · Granted May 10, 2005

Methods of preventing aggregation of various substances upon rehydration or thawing and compositions obtained thereby

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Quick Facts
Patent No.
US 6,890,512
App. No.
09/836,625
Granted
May 10, 2005
Kind
B2
Abstract

The present invention encompasses methods to prevent aggregation of a wide variety of substances during freezing/thawing and/or dehydrating/rehydrating. The substances thus obtained and compositions comprising the substances are also encompassed by the invention.

Claims (7)

1. A method of preventing aggregation during dehydration and rehydration of particulates in suspension comprising the steps of:

adding to a particulate suspension a final concentration between 10% and 50% (w/v) of trehalose sufficient to prevent aggregation upon rehydration; and

dehydrating the suspension.

2. The method according to claim 1 , wherein the particulates are selected from the group consisting at colloidal gold and polystyrene latex.

3. The method according to claim 1 , wherein the amount of trehalose is at least 30% (w/v).

4. The method according to claim 1 , wherein the particulate is aluminum hydroxide and the amount of trehalose is at least 15% (w/v).

5. The method according to claim 4 , wherein the amount of trehalose is at least 30% (w/v).

Assignments (1)
CHANGE OF NAME Recorded Dec 26, 2006
From: ELAN DRUG DELIVERY LIMITED
To: QUADRANT DRUG DELIVERY LIMITED
Reel/Frame 018668/0751 →