Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
View Patent ↗Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
1. A pharmaceutical composition comprising:
(a) a cyclodextrin; and
(b) a lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof.
2. The pharmaceutical composition of claim 1 which further comprises water.
3. The pharmaceutical composition of claim 1 which is a powder.
4. The pharmaceutical composition of claim 1 which is a lyophilized powder.
5. A pharmaceutical composition comprising:
(a) an aqueous cyclodextrin carrier and
(b) a therapeutically effective amount of a lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof.
6. The pharmaceutical composition of claim 5 , wherein the pharmaceutical composition comprises:
(a) a therapeutically effective amount of a lipidated glycopeptide antibiotic or a pharmaceutically acceptable salt thereof;
(b) 1 to 40 weight percent of a cyclodextrin; and
(c) 60 to 99 weight percent of water based on 100 weight percent of the composition.
7. The pharmaceutical composition of claim 5 , wherein the cyclodextrin is hydroxypropyl-β-cyclodextrin or sulfobutyl ether β-cyclodextrin.
8. The pharmaceutical composition of claim 7 , wherein the cyclodextrin is hydroxypropyl-β-cyclodextrin.
9. The pharmaceutical composition of claim 6 , wherein the cyclodextrin comprises about 5 to 35 weight percent of the composition.
10. The pharmaceutical composition of claim 9 , wherein the cyclodextrin comprises about 10 to 30 weight percent of the composition.