IP Library › Granted Patent US 7,241,309
Granted Patent B2
US 7,241,309 · App. 09/877,867 · Granted Jul 10, 2007

Self-aggregating protein compositions and use as sealants

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Quick Facts
Patent No.
US 7,241,309
App. No.
09/877,867
Granted
Jul 10, 2007
Kind
B2
Abstract

There is described a bio-compatible aqueous slurry for forming a fluid-tight barrier on a surface of a porous implantable article. This aqueous slurry includes a self-aggregating protein comminutate having a substantially uniform particle size, a bio-compatible plasticizer and water. This aqueous slurry is further characterized by having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25° C. and a pH sufficient to maintain the protein suspended in the slurry.

Claims (21)

1. An implantable member for use in the body comprising:

a porous biocompatible substrate; and

an aqueous non-crosslinked sealant composition in intimate contact with said porous substrate for forming a substantially fluid-tight seal, wherein said sealant composition forms said substantially fluid-tight seal in absence of cross-linking, said sealant composition comprising:

a self-aggregating protein comminutate composition comprising particles of substantially the same diameter and water;

wherein said protein composition has a pH sufficient to maintain said protein comminutate in particulate form.

2. The implantable member of claim 1 , wherein said sealant composition further comprises a plasticizer.

3. The implantable member of claim 1 , wherein said sealant composition is in a dry state on said substrate.

4. The implantable member of claim 1 , wherein said sealant composition further comprises a platicizer.

5. The implantable member of claim 1 , wherein said self-aggregating protein is present in said sealant composition at concentrations of from about 1% to about 3% by weight.

6. The implantable member of claim 1 , wherein said self-aggregating protein is selected from the group consisting of collagen, fibronectin, vitronectin, proteoglycan, laminin, hyaluronic acid, tenascin, integrin, cadherin and mixtures thereof.

7. The implantable member of claim 6 , wherein said self-aggregating protein is type I bovine collagen.

8. The implantable member of claim 1 , wherein said sealant composition further comprises a permeability lowering composition.

9. The implantable member of claim 8 , wherein said permeability lower composition comprises from about 0% to about 24% ethanol.

10. The implantable member of claim 4 , wherein said plasticizer is one of glycerol and sorbitol.

11. The implantable member of claim 4 , wherein said plasticizer is present in said sealant composition at about 8% to about 30% by weight.

12. The implantable member of claim 1 , wherein said sealant composition further comprises a bio-active agent.

13. The implantable member of claim 10 , wherein said bio-active agent is selected from the group consisting of antibiotics, anticoagulants, antibacterial agents and mixtures thereof.

14. The implantable member of claim 1 , wherein said sealant composition has a viscosity of about 30,000 centipose to about 50,000 centipoise.

15. The implantable member of claim 1 , wherein said pH is in a range sufficiently outside the isoelectric point of said protein comminutate to maintain said protein in an aqueous state.

16. The implantable member of claim 1 , wherein said pH is from about 3.5 to about 3.9.

17. The implantable member of claim 1 , wherein said sealant composition has a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25° C.