Water-soluble stabilized self-assembled polyelectrolytes
View Patent ↗The present invention is directed toward water-soluble supramolecular self-assemblies and a process for their preparation via micellization of polyelectrolytes through the use of hydrophobic monomeric units. In this invention the polyelectrolyte segment ultimately forms the core of the supramolecular assembly whereas the shell consists of uncharged hydrophilic polymers or oligomers. It has been determined that the inclusion of the hydrophobic co-monomers to the polyelectrolyte segment forming the micelle core leads to a structure of enhanced stability.
1. Multimolecular micelles consisting essentially of polyelectrolyte copolymers including at least one hydrophobic block and at least one hydrophilic block wherein:
1) said at least one hydrophobic block comprises ionizable and/or charged repeating monomers in combination with nonionic hydrophobic repeating monomers; wherein the ionizable and/or charged repeating monomers include at least one compound selected from the group consisting of alkylacrylic acid derivatives, acrylic acid derivatives, aminoalkylacrylate derivatives, and (amino alkyl) alkylacrylate derivatives, and wherein the non-ionic hydrophobic repeating monomers include one or more hydrophobic vinyl compounds; and
2) said at least one hydrophilic block, comprises a nonionic hydrophilic polymer or oligomer that is polyethylene glycol or that is synthesized from hydrophilic vinyl monomers; and
wherein said hydrophobic block comprising ionizable and/or charged repeating monomers in combination with the nonionic hydrophobic repeating monomers forms a micellar core and said hydrophilic block forms the exterior of the micelle.
2. The multimolecular micelles of claim 1 wherein each said polyelectrolyte copolymer is a graft copolymer wherein:
1) said hydrophobic block serves as a backbone to which said hydrophilic polymers or oligomers are grafted, wherein said hydrophobic block comprises ionizable and permanently-charged amphiphilic random copolymers including at least one compound selected from the group consisting of alkylacrylic acid derivatives, acrylic acid derivatives, aminoalkylacrylate derivatives, and (amino alkyl) alkylacrylate derivatives in combination with said nonionic hydrophobic repeating monomers; or
2) said hydrophilic block serves as a backbone to which one or more hydrophobic blocks of claim 1 are grafted.
3. The multimolecular micelle of claim 1 wherein:
said one or more hydrophobic vinyl compounds are selected from the group consisting of acrylates, acrylamides, alkylacrylates, alkylacrylamides, arylacrylates, and arylacrylamides.
4. The multimolecular micelle of claim 3 wherein:
said one or more hydrophobic vinyl compounds comprise at least one aliphatic or aromatic moiety selected from the group consisting of methacrylates and methacrylamides.
5. The multimolecular micelle of claim 3 wherein:
said hydrophobic repeating monomers form at least one vinyl-terminated biodegradable polyester.
6. The multimolecular micelle of claim 1 wherein:
said at least one hydrophilic block comprises at least one repeating unit selected from the group consisting of acrylates, acrylamides, alkylacrylates, alkylacrylamides, and N-vinyl-2-pyrrolidones.
7. The multimolecular micelles of claim 6 , wherein:
said hydrophilic block originates from a macroinitiator comprising a poly(ethylene glycol) or a poly (N-vinyl-2-pyrrolidone).
8. The multimolecular micelle of claim 2 wherein:
said one or more hydrophobic vinyl compounds are selected from the group consisting of acrylates, acrylainides, alkylacrylates, alkylacrylamides, arylacrylates, and arylacrylamides.
9. The multimolecular micelle of claim 8 wherein:
said one or more hydrophobic vinyl compounds comprise at least one aliphatic or aromatic moiety selected from the group consisting of methacrylates and methacrylamides.
10. The multimolecular micelle of claim 8 wherein:
said hydrophobic repeating monomers form at least one vinyl terminated biodegradable polyester.
11. The multimolecular micelle of claim 2 wherein:
said hydrophilic vinyl monomers are selected from the group consisting of acrylates, acrylamides, alkylacrylates, alkylacrylamides, and N-vinyl-2-pyrrolidones.