Antibodies to interleukin-1 receptor intracellular ligand proteins
View Patent ↗Antibodies to IL-1-R intracellular ligand proteins are disclosed. The antibodies arc useful for inhibiting the binding between IL-1-R and IL-1-R intracellular ligand proteins.
1. An isolated antibody which specifically binds to an IL-1-R intracellular ligand protein comprising the amino acid sequence of SEQ ID NO:2, wherein said antibody specifically binds to an epitope in SEQ ID NO:2.
2. The antibody of claim 1 , wherein said antibody is a neutralizing antibody.
3. The antibody of claim 1 , wherein said antibody blocks binding of IL-1-R to an IL-1-R intracellular ligand protein consisting of the amino acid sequence of SEQ ID NO:2.
4. The antibody of claim 1 , wherein said antibody is a polyclonal antibody.
5. The antibody of claim 1 , wherein said antibody is a monoclonal antibody.
6. The antibody of claim 1 , wherein said antibody is obtained using as an immuniogen an IL-1-R intracellular ligand protein with a cysteine residue at the carboxyl terminus, wherein said protein consists of the amino acid sequence of SEQ ID NO:2.
7. A pharmaceutical composition comprising the antibody of claim 1 and a pharmaceutically acceptable carrier.
8. An isolated, neutralizing antibody that binds specifically to an IL-1-R intracellular ligand protein consisting of the amino acid sequence of SEQ ID NO:2, wherein said neutralizing antibody blocks binding of IL-1-R to said IL-1-R intracellular ligand protein.
9. A pharmaceutical composition comprising the antibody of claim 8 and a pharmaceutically acceptable carrier.
10. An isolated antibody which specifically binds to an IL-1-R intracellular ligand protein consisting of the amino acid sequence of SEQ ID NO:2.