Methods of treating central nervous system disorders using viral vectors
View Patent ↗Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
1. A method of delivering recombinant adeno-associated virus virions to the brain of a subject suffering from a central nervous system (CNS) disorder, comprising:
(a) providing a composition comprising recombinant adeno-associated virus virions, said recombinant adeno-associated virus virions encoding a protein; and
(b) administering said composition to the brain of the subject such that distribution of said recombinant adeno-associated virus virions over an area greater than 5 mm 2 is achieved, wherein said recombinant adeno-associated virus virions are administered by convection enhanced delivery using a pump.
2. The method of claim 1 , wherein said convection enhanced delivery is performed using an infusion pump.
3. The method of claim 2 , wherein distribution of said recombinant adeno-associated virus virions is over an area of at least about 50 mm 2 .
4. The method of claim 1 , wherein said convection enhanced delivery is performed using an osmotic pump.
5. The method of claim 4 , wherein distribution of said recombinant adeno-associated virus virions is over an area of at least about 50 mm 2 .
6. The method of claim 1 , wherein said recombinant adeno-associated virus virions are administered to the striatum.
7. The method of claim 1 , wherein distribution of said recombinant adeno-associated virus virions is over an area of at least about 50 mm 2 .