Method and preparation for the preventing and/or treating vascular disorders and secondary disorders associated therewith

1. A method for treating a person having unipolar depression comprising administering orally to said person a preparation comprising:

a) long chain polyunsaturated fatty acids comprising ω-3 and ω-6 fatty acids, in an amount of at least 350 mg per day;

b) a mixture of phospholipids comprising phosphatidyl-choline and phosphatidylethanolamine and at least one of phosphatidylserine and phosphatidylinositol, wherein said phospholipids are in a ratio of phosphatidylcholine and phosphatidylethanolamine to phosphatidylserine and phosphatidylinositol is between 0.5:1 and 20:1 (wt/wt), and

c) at least one compound which is a factor in methionine metabolism, selected from the group consisting of folate, vitamin B12, vitamin B6, magnesium and zinc.

2. The method according to claim 1 , wherein the preparation further comprises at least one of hypericin and extract of Withania somnifera.

3. The method according to claim 1 , further comprising administering citrate in an amount of 0.5 to 30 g per day.

4. The method according to claim 1 , wherein the preparation further comprises tryptophan, or a protein containing tryptophan.

5. The method according to claim 1 , wherein the ω-3 fatty acids are selected from the group consisting of eicosapentaenoic acid and docosahexaenoic acid and the ω-6 fatty acids are selected from the group consisting of arachidonic acid and dihomogammalinolenic acid.

6. The method according to claim 1 , wherein c) contains at least folate and vitamin B6.

7. The method according to claim 1 , wherein the preparation further comprises at least one member selected from SAMe, choline, betaine and copper.

8. The method according to claim 1 , further comprising administering zinc and copper, wherein the weight ratio of zinc to copper is between 5:1 and 12:1.

9. The method according to claim 1 , wherein the preparation further comprises at least one member selected from the group consisting of carnitine, vitamin B1, vitamin B5 and coenzyme Q10.

10. The method according to claim 1 , wherein the preparation further comprises at least one antioxidant selected from vitamin C, vitamin E, lipoic acid, selenium salt and carotenoids.

11. The method according to claim 1 , wherein the preparation further comprises an extract of ginkgo biloba.

12. The method according to claim 1 , wherein the preparation further comprises vitamin D.

13. The method according to claim 1 , wherein the preparation comprises folate, citrate, at least one of hypericin and extract of Withania somnifera , and wherein the method comprises administering the preparation in an amount which provides a daily dose of:

at least 120 mg of long chain polyunsaturated fatty acids;

at least 200 mg phospholipids;

at least 200 μg folate;

at least one of at least 0.1 mg hypericin and at least 100 mg extract of Withania somnifera and

at least 500 mg citrate.

14. The method of claim 1 further comprising administering phospholipids in an amount of at least 1 g per day.

15. The method according to claim 1 , wherein said ω-3 and ω-6 fatty acids are in a ratio of ω-3 fatty acids to ω-6 fatty acids to about 2.5:1 and 5.5:1 (wt/wt).

16. A method for treating a person having unipolar depression comprising administering orally to said person in need thereof an effective amount of a preparation comprising:

a) long chain polyunsaturated fatty acids comprising ω-3 and ω-6 fatty acids in an amount of at least 350 mg per day, wherein the ω-3 fatty acids comprise eicosapentaenoic acid and docosahexaenoic acid and the ω-6 fatty acids comprise at least one of arachidonic acid and dihomogammalinolenic acid, and wherein said ω-3 and ω-6 fatty acids are in a ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid and dihomogammalinolenic acid between 2.5:1 and 5.5:1 (wt/wt);

b) at least two different phospholipids selected from the group consisting of phosphatidylserine, phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine, and

c) at least one compound which is a factor in methionine metabolism, selected from the group consisting of folate, vitamin B12, vitamin B6, magnesium and zinc.

17. The method according to claim 16 , wherein the preparation comprises eicospentaenoic acid, docosahexaenoic acid, arachidonic acid, magnesium, zinc, vitamin B6 and vitamin B12 and wherein the method comprises administering the preparation in an amount which provides a daily dose of:

at least 20 mg eicosapentaenoic acid;

at least 50 mg docosahexaenoic acid;

at least 50 mg arachidonic acid;

at least 200 mg phospholipids;

at least 200 μg folate;

at least one of at least 0.2 mg hypericin and at least 500 mg Withania somnifera extract;

at least 100 mg magnesium;

at least 5 mg zinc;

at least 2 mg vitamin B6;

at least 2 μg vitamin 312; and at least 1.0 g citrate.

18. The method for treating unipolar depression according to claim 16 , wherein said phospholipids are in a ratio of phosphatidylcholine and phosphatidylethanolamine to phosphatidylserine and phosphatidylinositol of 0.5–20:1 (wt/wt).