BAFF, inhibitors thereof and their use in the modulation of B-cell response
View Patent ↗The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
1. A method of inhibiting B-cell growth in an animal comprising the step of administering a therapeutically effective amount of an anti-BAFF antibody that binds human BAFF (SEQ ID NO:1), wherein B-cell growth in the animal is inhibited.
2. A method of inhibiting immunoglobulin production in an animal comprising the step of administering a therapeutically effective amount of an anti-BAFF antibody that binds human BAFF (SEQ ID NO:1), wherein immunoglobulin production in the animal is inhibited.
3. A method of co-inhibiting B-cell growth and immunoglobulin production in an animal comprising the step of administering a therapeutically effective amount of an anti-BAFF antibody that binds human BAFF (SEQ ID NO:1), wherein B-cell growth and immunoglobulin production in the animal are inhibited.
4. A method of inhibiting B-cell growth and maturation in an animal comprising the step of administering a therapeutically effective amount of an anti-BAFF antibody that binds human BAFF (SEQ ID NO:1), wherein B-cell growth and maturation in the animal are inhibited.
5. A method of inhibiting B-cell growth in an animal comprising the step of administering a therapeutically effective amount of an anti-BAFF antibody that binds murine BAFF (SEQ ID NO:2), wherein B-cell growth in the animal is inhibited.
6. A method of inhibiting immunoglobulin production in an animal comprising the step of administering a therapeutically effective amount of an anti-BAFF antibody that binds murine BAFF (SEQ ID NO:2), wherein immunoglobulin production in the animal is inhibited.
7. A method of co-inhibiting B-cell growth and immunoglobulin production in an animal comprising the step of administering a therapeutically effective amount of an anti-BAFF antibody that binds murine BAFF (SEQ ID NO:2), wherein B-cell growth and immunoglobulin production in the animal are inhibited.
8. A method of inhibiting B-cell growth and maturation in an animal comprising the step of administering a therapeutically effective amount of an anti-BAFF antibody that binds murine BAFF (SEQ ID NO:2); wherein B-cell growth and maturation in the animal are inhibited.
9. The method according to any one of claims 1 - 8 , wherein the anti-BAFF antibody is a monoclonal antibody.
10. The methods of claim 9 , wherein the antibody is recombinantly produced.
11. The method as in claim 9 , wherein the antibody is a chimeric antibody.
12. The method as in claim 9 , wherein the antibody is a humanized antibody.
13. The method as in claim 9 , wherein the antibody comprises human constant domains.
14. The method as in claim 9 , wherein the antibody is a F(ab') 2 fragment.