Dalfopristine/quinupristine combinations with cefpirome
View Patent ↗A pharmaceutical composition comprising synergistically effective amounts of cefpirome and dalfopristine/quinupristine combination. A method of treating a patient comprising the administration of synergistically effective amounts of cefpirome and a dalfopristine/quinupristine combination. Kits comprising synergistically effective amounts of cefpirome and a dalfopristine/quinupristine combination are also disclosed.
1. A pharmaceutical composition comprising synergistically effective amounts of:
(A) cefpirome, and
(B) a dalfopristine/quinupristine combination.
2. A pharmaceutical composition according to claim 1 , wherein quinupristine and dalfopristine are present in a ratio of approximately 30:70.
3. A pharmaceutical composition according to claim 1 , wherein said dalfopristine/quinupristine combination is in a liquid, lyophilized, or frozen form.
4. A method for treating a bacterial infection in a patient, said method comprising administering to a patient in need there of synergistically effective amounts of:
(A) cefpirome, and
(B) a dalfopristine/quinupristine combination.
5. A method for treating a bacterial infection in a patient according to claim 4 , wherein said cefpirome and said dalfopristine/quinupristine combination are administered simultaneously or sequentially.
6. A method for treating a bacterial infection in a patient according to claim 4 , wherein said cefpirome and said dalfopristine/quinupristine combination are administered through a multilumen catheter.
7. A method for treating a bacterial infection in a patient according to claim 4 , wherein said cefpirome and said dalfopristine/quinupristine combination are administered in the form of two infusion bags, one containing the cefpirome and the other containing the dalfopristine/quinupristine combination.
8. A method for treating a bacterial infection in a patient according to claim 4 , wherein said cefpirome and said dalfopristine/quinupristine combination are administered in the form of two syringes, one containing the cefpirome and the other containing the dalfopristine/quinupristine combination.
9. A method for treating a bacterial infection in a patient according to claim 4 , wherein said cefpirome and said dalfopristine/quinupristine combination are administered in the form of an infusion bag and a syringe, with one containing the cefpirome and the other containing the dalfopristine/quinupristine combination.
10. A method for treating a bacterial infection in a patient according to claim 4 , wherein said patient is in need of treatment for infections caused by both gram-positive and gram-negative microorganisms.
11. A method for treating a bacterial infection according to claim 4 , wherein the dalfopristine/quinupristine combination is administered to said patient in an amount ranging from about 5 to about 60 mg/kg/day and the cefpirome is administered in an amount ranging from about 2 to about 4 g/day.
12. A method for treating a bacterial infection according to claim 4 , wherein the dalfopristine/quinupristine combination is administered to said patient in an amount ranging from about 10 to about 30 mg/kg/day and the cefpirome is administered in an amount ranging from about 2 to about 4 g/day.
13. A method for treating a bacterial infection according to claim 11 , wherein the cefpirome is administered in two infusions, two direct intravenous injections, or one infusion and one direct intravenous injection.
14. A method for treating a bacterial infection according to claim 12 , wherein the cefpirome is administered in two infusions, two direct intravenous injections, or one infusion and one direct intravenous injection.
15. A method for treating endocarditis, said method comprising administering to a patient in need of such treatment synergistically effective amounts of cefpirome and a dalfopristine/quinupristine combination.