IP Library › Granted Patent US 7,094,402
Granted Patent B2
US 7,094,402 · App. 09/924,338 · Granted Aug 22, 2006

Antibodies to human interleukin-11 receptor

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Quick Facts
Patent No.
US 7,094,402
App. No.
09/924,338
Granted
Aug 22, 2006
Kind
B2
Abstract

Polynucleotides encoding the human IL-11 receptor and fragments thereof are disclosed. IL-11 receptor proteins, methods for their production, antibodies to human IL-11 receptor, inhibitors of binding of human IL-11 and its receptor and methods for identification of their receptor are also disclosed.

Claims (21)

1. An isolated antibody that specifically binds to a human interleukin-11 receptor (IL-11R) protein or a fragment thereof, wherein the human IL-11R protein or fragment thereof consists of an amino acid sequence selected from the group consisting of:

(a) the amino acid sequence of SEQ ID NO:2;

(b) the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 422;

(c) the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 365;

(d) the amino acid sequence of SEQ ID NO:2 from amino acids 391 to 422;

(e) the amino acid sequence of SEQ ID NO:2 from amino acids 112 to 422;

(f) the amino acid sequence of SEQ ID NO:2 from amino acids 112 to 365;

(g) the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 359;

(h) the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 345; and

(i) the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 324.

2. The antibody of claim 1 , wherein said antibody is a neutralizing antibody.

3. The antibody of claim 1 , wherein said antibody blocks binding of IL-11 to a human IL-11 receptor.

4. The antibody of claim 1 , wherein said antibody is a polyclonal antibody.

5. The antibody of claim 1 , wherein said antibody is a monoclonal antibody.

6. A pharmaceutical composition comprising the antibody of claim 1 and a pharmaceutically acceptable carrier.

7. An isolated antibody that specifically binds to a human interleukin-11 receptor (IL-11R) consisting of the amino acid sequence of SEQ ID NO:2 or consisting of the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 422.

8. The isolated antibody of claim 7 , wherein said antibody is a neutralizing antibody.

9. The antibody of claim 7 , wherein said antibody blocks binding of IL-11 to a human IL-11 receptor.

10. The antibody of claim 7 , wherein said antibody is a polyclonal antibody.

11. The antibody of claim 7 , wherein said antibody is a monoclonal antibody.

12. A pharmaceutical composition comprising the antibody of claim 7 and a pharmaceutically acceptable carrier.