Treatment of addiction and addiction-related behavior
View Patent ↗The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of behavior associated with addiction to drugs of abuse in said mammal.
1. A method for treating addiction to cocaine in a mammal, wherein said method comprises administering an effective amount of a composition consisting essentially of topiramate or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof, to said mammal.
2. A method according to claim 1 , wherein said topiramate is administered in an amount of about 25 mg to about 1 g/day.
3. A method for treating addiction to nicotine in a mammal, wherein said method comprises administering an effective amount of a composition consisting essentially of topirarnate or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof, to said mammal.
4. A method according to claim 3 , wherein said topiramate is administered in an amount of about 25 mg to about 1 g/day.
5. A method for treating addiction to morphine in a mammal, wherein said method comprises administering an effective amount of a composition consisting essentially of topiramate or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof, to said mammal.
6. A method according to claim 5 , wherein said topiramate is administered in an amount of about 25 mg to about 1 g/day.
7. A method for treating addiction to methamphetamine in a mammal, wherein said method comprises administering an effective amount of a composition consisting essentially of topiramate or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof, to said mammal.
8. A method according to claim 7 , wherein said topiramate administered in an amount of about 25 mg to about 1 g/day.
9. A method for treating addiction to alcohol in a mammal, wherein said method comprises administering an effective amount of a composition consisting essentially of topiramate or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof, to said mammal.
10. A method according to claim 9 , wherein said topiraniate is administered in an amount of about 25 mg to about 1 g/day.
11. A method for treating addiction to phencyclidine in a mammal, wherein said method comprises administering an effective amount of a composition consisting essentially of topiramate or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof, to said mammal.
12. A method according to claim 11 , wherein said topiramate is administered in an amount of about 25 mg to about 1 g/day.
13. A method for treating addiction to methylenedioxymethamphetamine in a mammal, wherein said method comprises administering an effective amount of a composition consisting essentially of topiramate or a pharmaceutically acceptable salt thereof, or an enantiomer or racemic mixture thereof, to said mammal.
14. A method according to claim 13 , wherein said topiramate administered in an amount of about 25 mg to about 1 g/day.
15. A method of treating addiction to a combination of drugs of abuse in a mammal, wherein said method comprises administering an effective amount of a composition consisting essentially of topiramate for a pharmaceutically acceptable salt thereof or an enantiomer or racemic mixture thereof, to said mammal.
16. A method according to claim 15 , wherein said topiramate is administered in an amount of about 25 mg to about 1 g/day.
17. A method according to claim 15 , wherein said combination of drugs of abuse is selected from the group consisting of psychostimulants, narcotic analgesics, alcohols, addictive alkaloids or combinations thereof.
18. A method according to claim 15 , wherein said combination of drugs of abuse is selected from the group consisting of cocaine, nicotine, methamphetamine, morphine, heroin, ethanol, phencyclidine, methylenedioxymethamphetamine, or combinations thereof.
19. A method for treating addiction to heroin in a mammal, wherein said method comprises administering an effective amount of a composition consisting essentially of topiraniate or a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof, to said mammal.
20. A method according to claim 19 , wherein said topiramate administered in an amount of about 25 mg to about 1 g/day.