Bone graft substitute composition
View Patent ↗A bone graft substitute composition can include essentially of calcium sulfate, a mixing solution, and a plasticizing substance. A bone graft substitute composition can include calcium sulfate, demineralized bone matrix, cancellous bone, a plasticizing substance, and a mixing solution.
1. A bone graft substitute composition, comprising:
about 80 to about 120 parts by weight of calcium sulfate;
about 10 to about 100 parts by weight of demineralized bone matrix;
about 20 to about 130 parts by weight of cancellous bone;
about 1 to about 40 parts by weight of a plasticizing substance; and
about 21 to about 250 parts by weight of a mixing solution, wherein the cancellous bone has a particle size between about 1 and about 4 mm.
2. The composition of claim 1 , wherein the calcium sulfate comprises calcium sulfate hemihydrate.
3. The composition of claim 1 , wherein the plasticizing substance comprises a cellulose derivative.
4. The composition of claim 1 , wherein the plasticizing substance is selected from a group consisting of sodium carboxymethylcellulose, methylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethylcellulose, hydroxyethylcellulose, and cellulose acetate butyrate.
5. The composition of claim 1 , wherein the mixing solution is selected from a group consisting of sterile water, inorganic salt, and cationic surface active agent.
6. The composition of claim 5 , wherein the cationic surface active agent is selected from a group consisting of sodium chloride, phosphate buffered saline, potassium chloride, sodium sulfate, ammonium sulfate, ammonium acetate, and sodium acetate.
7. The composition of claim 1 , wherein the mixing solution comprises sterile water.
8. The composition of claim 1 , wherein the mixing solution comprises a material selected from a group consisting of bone marrow aspirate, platelet concentrate, blood, an antibiotic, a chemotherapeutic agent, a growth factor, and an analgesic.
9. The composition of claim 1 , comprising:
about 90 to about 110 parts by weight of calcium sulfate;
about 10 to about 50 parts by weight of demineralized bone matrix;
about 15 to about 50 parts by weight of cancellous bone;
about 5 to about 20 parts by weight of a plasticizing substance; and
about 80 to about 120 parts by weight of a mixing solution.
10. The composition of claim 1 , comprising:
about 98 to about 102 parts by weight of calcium sulfate;
about 13 to about 23 parts by weight of demineralized bone matrix;
about 37 to about 46 parts by weight of cancellous bone;
about 15 to about 20 parts by weight of a plasticizing substance; and
about 95 to about 105 parts by weight of a mixing solution.
11. The composition of claim 1 , comprising:
about 100 parts by weight of calcium sulfate;
about 18 to about 19 parts by weight of demineralized bone matrix;
about 40 to about 42 parts by weight of cancellous bone;
about 17 to about 18 parts by weight of a plasticizing substance; and
about 101 to about 102 parts by weight of a mixing solution.
12. A bone graft substitute composition, comprising: about 80 to about 120 parts by weight of calcium sulfate;
about 10 to about 120 parts by weight of demineralized bone matrix;
about 20 to about 150 parts by weight of cancellous bone;
about 1 to about 40 parts by weight of a plasticizing substance; and
about 50 to about 300 parts by weight of a mixing solution, wherein the cancellous bone has a particle size between about 4 and about 10 mm.
13. The composition of claim 12 , wherein the calcium sulfate comprises calcium sulfate hemihydrate.
14. The composition of claim 12 , wherein the plasticizing substance comprises a cellulose derivative.
15. The composition of claim 12 , wherein the plasticizing substance is selected from a group consisting of sodium carboxymethylcellulose, methylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethylcellulose, hydroxyethylcellulose, and cellulose acetate butyrate.
16. The composition of claim 12 , wherein the mixing solution is selected from a group consisting of sterile water, inorganic salt, and cationic surface active agent.
17. The composition of claim 16 , wherein the cationic surface active agent is selected from a group consisting of sodium chloride, phosphate buffered saline, potassium chloride, sodium sulfate, ammonium sulfate, ammonium acetate, and sodium acetate.
18. The composition of claim 12 , wherein the mixing solution comprises sterile water.
19. The composition of claim 12 , wherein the mixing solution comprises a material selected from a group consisting of bone marrow aspirate, platelet concentrate, blood, an antibiotic, a chemotherapeutic agent, a growth factor, and an analgesic.
20. The composition of claim 12 , comprising:
about 90 to about 110 parts by weight of calcium sulfate;
about 10 to about 60 parts by weight of demineralized bone matrix;
about 40 to about 120 parts by weight of cancellous bone;
about 5 to about 20 parts by weight of a plasticizing substance; and
about 140 to about 180 parts by weight of a mixing solution.
21. The composition of claim 12 , comprising:
about 98 to about 102 parts by weight of calcium sulfate;
about 25 to about 35 parts by weight of demineralized bone matrix;
about 44 to about 110 parts by weight of cancellous bone;
about 15 to about 20 parts by weight of a plasticizing substance; and
about 160 to about 170 parts by weight of a mixing solution.
22. The composition of claim 12 , comprising:
about 100 parts by weight of calcium sulfate;
about 30 to about 32 parts by weight of demineralized bone matrix;
about 99 to about 105 parts by weight of cancellous bone;
about 17 to about 18 parts by weight of a plasticizing substance; and
about 162 to about 168 parts by weight of a mixing solution.
23. A kit for making a bone graft substitute composition, the kit comprising:
a first portion comprising:
about 80 to about 120 parts by weight of calcium sulfate;
about 10 to about 120 parts by weight of demineralized bone matrix;
a first portion of cancellous bone having a particle size between about 4 and about 10 mm; and
about 1 to about 40 parts by weight of a plasticizing substance;
a second portion comprising:
a second portion of cancellous bone having a particle size between about 4 and about 10 mm; and
a third portion comprising:
about 50 to about 300 parts by weight of a mixing solution,
wherein the first and second portions of cancellous bone total about 20 to about 150 parts by weight of cancellous bone.
24. The kit of claim 23 , wherein the first portion comprises about 40 to about 50 parts by weight of cancellous bone.
25. A method of preparing a bone graft substitute composition, the method comprising:
providing a first portion comprising:
about 80 to about 120 parts by weight of calcium sulfate;
about 10 to about 120 parts by weight of demineralized bone matrix;
a first portion of cancellous bone having a particle size between about 4 and about 10 mm; and
about 1 to about 40 parts by weight of a plasticizing substance;
providing a second portion comprising:
a second portion of cancellous bone having a particle size between about 4 and about 10 mm, wherein the first and second portions of cancellous bone total about 20 to about 150 parts by weight of cancellous bone;
providing a third portion comprising:
about 50 to about 300 parts by weight of a mixing solution; and
mixing the third portion with the first portion to form a bone graft substitute composition.
26. The method of claim 25 , further comprising mixing a portion of the second portion with the third and first portions.