Method for treating diseased or damaged organs
View Patent ↗A bioremodelable prosthesis for treating a patient with a diseased or damaged organs comprising a first layer that contains acid-extracted fibrillar or non-fibrillar collagen, and a second layer derived from the tunica submucosa of the small intestine that provides structural stability, is pliable and is semi-permeable,pe1 59564443.npc wherein the prosthesis undergoes controlled biodegradation occurring with adequate living cell replacement such that the original prosthesis is replaced by the patient's living cells.
1. A bioremodelable prosthesis for treating a patient with a diseased or damaged organ, comprising a first layer that contains acid-extracted fibrillar or non-fibrillar collagen, and a second layer derived from the tunica submucosa of the small intestine that provides structural stability, is pliable, and is semi-permeable, wherein said prosthesis all undergoes controlled biodegradation occurring with adequate living cell replacement such that the original prosthesis is replaced by the patient's living cells.
2. The prosthesis of claim 1 , wherein the prosthesis is tubular and the diseased or damaged organ is an artery or a vein.
3. The prosthesis of claim 2 , wherein the tubular prosthesis has a diameter of less than 6 mm.
4. The prosthesis of claim 2 , wherein the tubular prosthesis has a diameter of between 6 to 12 mm.
5. The prosthesis of claim 2 , wherein the tubular prosthesis has a diameter of greater than 12 mm.
6. The prosthesis of claim 1 , wherein the diseased or damaged organ is the esophagus, intestine, bowel, urethra, or fallopian tubes.
7. The prosthesis of claim 1 , wherein said first layer has a smooth flow surface.
8. The prosthesis of claim 7 , wherein the smooth flow surface is thrombosis-resistant.
9. The prosthesis of claim 1 , wherein said second layer is crosslinked.
10. The prosthesis of claim 9 , wherein said second layer is crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC).
11. The prosthesis of claim 1 , wherein said second layer has a thickness of between about 50 microns to about 150 microns.
12. The prosthesis of claim 1 , wherein the tunica submucosa of the small intestine is mechanically cleaned to remove the tunica muscularis and the tunica mucosa.
13. The prosthesis of claim 12 , wherein said mechanically cleaned tunica submucosa is chemically cleaned.
14. The prosthesis of claim 1 , wherein the tunica submucosa of the small intestine is sterilized.
15. The prosthesis of claim 1 , wherein said prosthesis further comprises a third layer.
16. The prosthesis of claim 1 , wherein the first layer is on the inside of the prosthesis.
17. The prosthesis of claim 1 , wherein the second layer is on the inside of the prosthesis.
18. The prosthesis of claim 1 , wherein the prosthesis is treated with a drug.
19. The prosthesis of claim 1 , wherein the first layer is treated with a drug.
20. The prosthesis of claim 1 , wherein the second layer is treated with a drug.
21. The prosthesis of claim 18 , 19 , or 20 , wherein the drug is heparin.
22. The prosthesis of claim 18 , 19 , or 20 , wherein the drug is a growth factor.